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Full-Text Articles in Biomedical Engineering and Bioengineering
Bone Properties By Nanoindentation In Mild And Severe Osteogenesis Imperfecta, Carolyne Albert, John Jameson, Jeffrey M. Toth, Peter Smith, Gerald F. Harris
Bone Properties By Nanoindentation In Mild And Severe Osteogenesis Imperfecta, Carolyne Albert, John Jameson, Jeffrey M. Toth, Peter Smith, Gerald F. Harris
Biomedical Engineering Faculty Research and Publications
Background
Osteogenesis imperfecta is a heterogeneous genetic disorder characterized by bone fragility. Previous research suggests that impaired collagen network and abnormal mineralization affect bone tissue properties, however, little data is yet available to describe bone material properties in individuals with this disorder. Bone material properties have not been characterized in individuals with the most common form of osteogenesis imperfecta, type I.
Methods
Bone tissue elastic modulus and hardness were measured by nanoindentation in eleven osteotomy specimens that were harvested from children with osteogenesis imperfecta during routine surgeries. These properties were compared between osteogenesis imperfecta types I (mild, n = …