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Hydrodynamic Assessment Of A Porcine Small Intestinal Sub-Mucosa Bioscaffold Valve For Pediatric Mitral Valve Replacement, Omkar V. Mankame
Hydrodynamic Assessment Of A Porcine Small Intestinal Sub-Mucosa Bioscaffold Valve For Pediatric Mitral Valve Replacement, Omkar V. Mankame
FIU Electronic Theses and Dissertations
Valve replacement for critical heart valve diseases is in many cases not an option. Our clinical experience in pediatric compassionate care has shown robust function of porcine small intestinal submucosa (PSIS) valves. We assessed functional effectiveness of 4ply (~320µm) and 2ply (~166µm) PSIS mitral valves under pediatric-relevant hemodynamic pulsatile conditions. Key conclusions: (i)PSIS valves demonstrated statistically similar acute functionality in comparison to a commercially available valve. (ii)Energy losses were similar (p>0.05) under pediatric conditions which was not the case under adult aortic conditions. (iii)2ply valves were observed to be superior to 4ply, based on the robust hydrodynamic data, the …