Biomedical Engineering and Bioengineering Commons^™

Assessment Of Electrospinning As An In-House Fabrication Technique For Blood Vessel Mimic Cellular Scaffolding, Colby M. James

Master's Theses

Intravascular devices, such as stents, must be rigorously tested before they can be approved by the FDA. This includes bench top in vitro testing to determine biocompatibility, and animal model testing to ensure safety and efficacy. As an intermediate step, a blood vessel mimic (BVM) testing method has been developed that mimics the three dimensional structure of blood vessels using a perfusion bioreactor system, human derived endothelial cells, and a biocompatible polymer scaffold used to support growth of the blood vessel cells. The focus of this thesis was to find an in-house fabrication method capable of making cellular scaffolding for …

Preparation And Characterization Of Electrospun Poly(D, L-Lactide-Co-Glycolide) Scaffolds For Vascular Tissue Engineering And The Advancement Of An In Vitro Blood Vessel Mimic, Tiffany Richelle Pena

Master's Theses

PREPARATION AND CHARACTERIZATION OF ELECTROSPUN POLY(D,L-LACTIDE-CO-GLYCOLIDE) SCAFFFOLDS FOR VASCULAR TISSUE ENGINEERING AND THE ADVANCEMENT OF AN IN VITRO BLOOD VESSEL MIMIC

Tiffany Richelle Peña

Currently, an estimated 1 in every 3 adult Americans are affected by one or more cardiovascular complications. The most common complication is coronary artery disease, specifically atherosclerosis. Outcomes of balloon angioplasty treatments have been significantly improved with the addition of drug eluting stents to the process. Although both bare metal and drug eluting stents have greatly increased the effectiveness of angioplasty and decreased the occurrence of restenosis, several complications still exist. For this reason, the stent …