Biomedical Engineering and Bioengineering Commons^™

Improved Manufacturing Methods Of Bovine Femur Samples For Ultrasonic Testing And Assessment Of Materials Through Contract Angle Measurement, Kevin Mathew Lopez Galang

Biomedical Engineering

At California Polytechnic State University of San Luis Obispo (Cal Poly), the Biomedical Engineering department (BMED) requires its students to take the course listed as “BMED 420: Principles of Biomaterial Designs.” BMED 420 has a required laboratory section every week throughout the duration of the course that is meant to be a supplemental tool for learning. During the lab sections, students perform experiments and exercises that are currently being implemented in the industry. Despite accuracy of the methods and experiments relative to their use in the industry, there is always room for improvement. The objective of this project will illustrate …

Targeted Multistage Delivery Of Nanoparticles To The Bone Marrow, Aman Mann

Dissertations & Theses (Open Access)

Bone marrow is a target organ site involved in multiple diseases including myeloproliferative disorders and hematologic malignancies and metastases from breast and prostate. Most of these diseases are characterized with poor quality of life, and the treatment options are only palliative due to lack of delivery mechanisms for systemically injected drugs which results in dose limitation to protect the healthy hematopoietic cells. Therefore, there is a critical need to develop effective therapeutic strategies that allow for selective delivery of therapeutic payload to the bone marrow. Nanotechnology-based drug delivery systems provide the opportunity to deliver drugs to the target tissue while …

Characterization And Implementation Of A Decellularized Porcine Vessel As A Biologic Scaffold For A Blood Vessel Mimic, Aubrey N. Smith

Master's Theses

Every 34 seconds, someone in the United States suffers from a heart attack. Most heart attacks are caused by atherosclerotic build up in the coronary arteries, occluding normal blood flow. Balloon angioplasty procedures in combination with a metal stent often result in successful restoration of normal blood flow. However, bare metal stents often lead to restenosis and other complications. To compensate for this problem, industry has created drug-eluting stents to promote healing of the artery wall post stenting. These stents are continually advancing toward better drug-eluting designs and methods, resulting in a need for fast and reliable pre-clinical testing modalities. …

Development Of An In-Vitro Hyperglycemic Tissue Engineered Blood Vessel Mimic, Brian C. Wong

Biomedical Engineering

No abstract provided.

Characterization And Implementation Of Low Intensity Pulsed Ultrasound As A Tool To Apply Physical Load To Scaffolds And Bone Cells For Fracture Repair, Scott Frazee

Master's Theses

One current challenge in treating bone fractures is the effective treatment of non-unions and delayed unions. Low Intensity Pulsed Ultrasound (LIPUS) has been approved by the FDA to treat fresh fractures since 1994 and non-unions since 2000 and is an attractive treatment option because it is non-invasive. The mechanism by which it works, however, is not well understood; what is known is largely confined to the resultant changes in chemical output of cells. In this thesis several concepts and techniques were brought together to investigate the following hypothesis: LIPUS produces a measurable physical load that results in measurable deformation and …

Mammary Epithelial Cell Growth On A Three-Dimensional Scaffold In An Operating Bioreactor, Melissa Marie Davalle

Master's Theses

Mammary epithelial cells are highly efficient secreting cells. With genetic engineering, the uses of these cells could be endless. Research is being conducted on these cells to determine their full potential to the biotech industry.

This paper investigates whether bovine epithelial mammary cells can survive in glutaraldehyde-treated gelatin tubes in an operating bioreactor. Many bioreactors were developed and tested to suit the needs of the cells. Procedures were created and carried out to ensure sterility of the bioreactors. Bovine mammary epithelial cells were implanted in the bioreactors and samples of their growth were taken over time.

Design And Development Of Two Test Fixtures To Test The Longitudinal And Transverse Tensile Properties Of Small Diameter Tubular Polymers, Carolyn Berry

Master's Theses

Hundreds of thousands of vascular bypass grafts are implanted in the United States every year, but there has yet to be an ideal graft material to substitute for one’s own autologous vessel. Many synthetic materials have been shown to be successful vessel replacements; however, none have been proven to exhibit the same mechanical properties as native vessels, one of the most important criteria in selecting a vascular graft material. Part of this issue is due to the fact that, currently, there is no “gold standard” for testing the longitudinal and transverse tensile properties of small diameter tubular materials. While there …