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Mucoadhesive Films For Treatment Of Local Oral Disorders: Development, Characterization And In Vivo Testing, Sandeep K. Ramineni
Mucoadhesive Films For Treatment Of Local Oral Disorders: Development, Characterization And In Vivo Testing, Sandeep K. Ramineni
Theses and Dissertations--Biomedical Engineering
Mucoadhesive drug delivery systems which are being used from 1980’s to avoid first pass metabolism of drugs, commercially exist for only systemic drug delivery with fast erosion times (15-60 min), that may not be appropriate for local oral disorders. The goal of this research was to develop and characterize mucoadhesive films with flexibility of carrying different drugs and proteins and provide sustained release for local treatment of oral disorders.
Mucoadhesive films composed of polyvinylpyrrolidone (PVP) and carboxymethlycellulose (CMC) were formulated with imiquimod, an immune response modifier. Problems such as solubilization of imiquimod to increase drug loading, uniformity in films and …