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Biomedical Engineering and Bioengineering Commons™
Open Access. Powered by Scholars. Published by Universities.®
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- 3D printing (1)
- Bioactive Glass (1)
- Bioceramics (1)
- Biomaterials (1)
- Cartilage regeneration (1)
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- Class II Organic/Inorganic Hybrid Biomaterials (1)
- Composites (1)
- Crosslinked polyethylene (1)
- Decellularization (1)
- Diethyl Fumarate (1)
- Drug delivery (1)
- Electroactive polymers (1)
- Extracellular matrix (1)
- Free Radical Polymerization (1)
- Hydrogels (1)
- Mechanical Properties (1)
- Microcarriers (1)
- Neck-shaft angle (1)
- Neural progenitor cells (1)
- Neural tissue regeneration (1)
- Polypyrrole (1)
- Reverse total shoulder arthroplasty (1)
- Scapular notching (1)
- Tribology (1)
- Triethoxyvinylsilane (1)
- Wear simulation (1)
Articles 1 - 4 of 4
Full-Text Articles in Biomedical Engineering and Bioengineering
Conducting Polypyrrole Hydrogel Biomaterials For Drug Delivery And Cartilage Tissue Regeneration, Iryna Liubchak
Conducting Polypyrrole Hydrogel Biomaterials For Drug Delivery And Cartilage Tissue Regeneration, Iryna Liubchak
Electronic Thesis and Dissertation Repository
Articular cartilage tissue has limited capacity for self-regeneration leading to challenges in the treatment of joint injuries and diseases such as osteoarthritis. The tissue engineering approach combines biomaterials, cells and bioactive molecules to provide a long-term and stable cartilage repair. In the following work, electroactive polymer polypyrrole~(PPy) was incorporated into the synthetic hydrogel to enhance the mechanical properties of the material for cartilage applications. PPy was loaded with drug compound and the \emph{on demand} drug release was demonstrated. The composite PPy hydrogel was 3D printed using stereolithography to create a porous tissue engineering scaffold. Biocompatibility and cell adhesion to the …
Motion And Crosslinked Polyethylene Wear In Reverse Total Shoulder Arthroplasty, Christopher Millward
Motion And Crosslinked Polyethylene Wear In Reverse Total Shoulder Arthroplasty, Christopher Millward
Electronic Thesis and Dissertation Repository
The reverse total shoulder arthroplasty (RTSA) has quickly grown to become the most commonly used shoulder arthroplasty design; however, reports have shown evidence of RTSA failures related to polyethylene wear and damage. Therefore, the present work investigated the wear of crosslinked polyethylene (XLPE) in environments similar to that of an in vivo RTSA. Additionally, a computational model was developed based on a previous study of the shoulder motions obtained from a selection of typical patients with RTSA. This model quantified the amount of glenohumeral motion that an RTSA may be subjected to in vivo and provided an approximate value for …
Development Of Brain-Derived Bioscaffolds For Neural Progenitor Cell Culture And Delivery, Julia Terek
Development Of Brain-Derived Bioscaffolds For Neural Progenitor Cell Culture And Delivery, Julia Terek
Electronic Thesis and Dissertation Repository
The use of brain extracellular matrix (ECM) as a biomaterial has the potential to promote neural tissue regeneration by providing cell-instructive cues that direct survival, proliferation, and differentiation. This study developed a novel detergent-free decellularization protocol that effectively reduced cellular content while preserving key ECM components in porcine and rat brains. The resulting decellularized brain tissue (DBT) was incorporated into microcarriers to assess its effects on the growth, phenotype and neurotrophic factor gene expression of rat brain-derived progenitor cells cultured within spinner flask bioreactors, using purified collagen microcarriers as a control. Both types of microcarriers supported cell expansion and survival, …
Sol-Gel Derived Bioceramic Poly(Diethyl Fumarate – Co – Triethoxyvinylsilane) Composite, Aref Sleiman
Sol-Gel Derived Bioceramic Poly(Diethyl Fumarate – Co – Triethoxyvinylsilane) Composite, Aref Sleiman
Electronic Thesis and Dissertation Repository
Synthetic bone graft materials have become an increasingly popular choice for bone augmentation. Ceramic-based and polymer-based bone graft materials constitute the two main classes of synthetic bone graft materials. This study investigated the synthesis of novel bioactive composites for their potential use as bone graft biomaterials. Poly(diethyl fumarate-co-triethoxyvinylsilane)/bioceramic class II organic/inorganic hybrid biomaterials were synthesized via a sol gel process. These biomaterials were then reacted with an ammonium phosphate solution to prepare their respective composites. For the first time, we successfully synthesized sol-gel derived bioceramic poly(diethyl fumarate-co-triethoxyvinylsilane) composites. In vitro bioactivity evaluation of poly(diethyl fumarate-co-triethoxyvinylsilane)/bioceramic composites in simulated body fluid …