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Biomedical Engineering and Bioengineering Commons™
Open Access. Powered by Scholars. Published by Universities.®
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- 3D printing (1)
- Additive manufacturing (AM) (1)
- Adipose tissue engineering; Adipose-derived stromal cells; Perfusion bioreactors; Decellularized adipose tissue; Angiogenesis; Immunomodulation; (1)
- Adipose-derived stromal cells (1)
- Antibacterial (1)
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- Bending strength (1)
- Cast (1)
- Cell delivery (1)
- Coatings (1)
- Cobalt chromium (Co-Cr) (1)
- Computer-aided design (CAD) (1)
- Computer-aided manufacturing (CAM) (1)
- Decellularized adipose tissue (1)
- Dental implants (1)
- Dental manufacturing (1)
- Drug delivery (1)
- Fibroblasts (1)
- Intra-articular (1)
- Lost-wax casting (1)
- Micro-CT imaging (1)
- Microenvironment (1)
- Milled (1)
- Nanoparticle (1)
- Orthopedic implants (1)
- Osseointegration (1)
- Osteoarthritis (1)
- Polymer (1)
- Porcelain-fused to metal (1)
- Selective laser melting (SLM) (1)
- Shear bond strength (1)
Articles 1 - 5 of 5
Full-Text Articles in Biomedical Engineering and Bioengineering
Development Of Hybrid Coating Materials To Improve The Success Of Titanium Implants, Zach Gouveia
Development Of Hybrid Coating Materials To Improve The Success Of Titanium Implants, Zach Gouveia
Electronic Thesis and Dissertation Repository
While titanium (Ti) and its alloys have become ubiquitous within implantology as materials to restore or augment the function of human tissues, their success is plagued by complications associated with infection and aseptic implant loosening. These two risks account for the majority of implant failures in the clinic and limit the long-term success of titanium implants in vivo. Therefore, this thesis describes the development of robust multifunctional class II organic-inorganic hybrid coating materials for titanium implants that could be used to effectively target both complications, concurrently. During this master’s work, two different coating systems were examined. First, class II …
Metal Additive Manufacturing For Fixed Dental Prostheses, Mai El Najjar
Metal Additive Manufacturing For Fixed Dental Prostheses, Mai El Najjar
Electronic Thesis and Dissertation Repository
The use of additive manufacturing (AM) in dentistry has gained momentum in recent years. However, high initial costs and uncertainty surrounding the quality of AM products are considered barriers to their use. This research compared dental substructures fabricated by AM versus conventional casting and milling.
Cobalt-chromium alloy rectangular bars and three-unit bridge substructures were fabricated by AM, casting or milling. Bars manufactured by AM exhibited superior flexural strength, shear bond strength of porcelain coating, and Vickers hardness. Bridge substructures fabricated by AM showed similar flexural stiffness to cast, similar flexural loads at failure to milled and cast, and overall accuracy …
3d Culture Strategies For The Dynamic Expansion And Preconditioning Of Adipose-Derived Stromal Cells On Decellularized Adipose Tissue Bioscaffolds, Tim Tian Han
Electronic Thesis and Dissertation Repository
Adipose tissue engineering holds promise for the development of therapeutic strategies for subcutaneous adipose tissue regeneration to treat defects resulting from congenital birth defects, invasive surgical procedures and traumatic injuries. Decellularized adipose tissue (DAT) scaffolds represent a potential off-the-shelf tissue substitute for volume augmentation. Seeding the DAT with adipose-derived stromal cells (ASCs) has been shown to enhance adipose tissue regeneration in immunocompetent animals in vivo. Although promising, this strategy is limited by low cell attachment on the DAT. As such, this thesis focused on the development of bioreactor strategies to enhance the capacity of human ASCs to stimulate angiogenesis …
Extracellular Matrix-Derived Modular Bioscaffolds For Soft Connective Tissue Regeneration, Pascal Morissette Martin
Extracellular Matrix-Derived Modular Bioscaffolds For Soft Connective Tissue Regeneration, Pascal Morissette Martin
Electronic Thesis and Dissertation Repository
Human decellularized adipose tissue (DAT) represents a promising extracellular matrix (ECM) source for the development of biomaterials, with its properties conductive of angiogenesis, adipogenesis, and scaffold remodelling. This thesis sought to provide new fundamental insight into the design of ECM-derived bioscaffolds by developing novel modular biomaterials for soft connective tissue regeneration and by studying the effects of ECM composition on cell function and fate.
Initial studies explored the effects of ECM composition of pre-assembled bead foams derived from DAT or commercially-sourced bovine collagen (COL) on human wound edge dermal fibroblasts (weDFs) sourced from chronic wounds. In vitro testing under conditions …
Preparation Of Intra-Articular Drug Delivery Systems For The Treatment Of Osteoarthritis, Ian Villamagna
Preparation Of Intra-Articular Drug Delivery Systems For The Treatment Of Osteoarthritis, Ian Villamagna
Electronic Thesis and Dissertation Repository
Osteoarthritis (OA) is a degenerative disease of the articular joints that affects over 240 million people globally. Despite its overwhelming prevalence, there is no disease modifying agent currently available to treat the disease, and many treatment options remain palliative in nature. Potentially effective treatments for OA are limited by probable systemic side effects. Intra-articular drug delivery systems present a new opportunity for the treatment of OA; encapsulated therapeutics can be injected directly into the joint, at the area of injury, thereby bypassing systemic administration and diminishing the chance for side effects. This thesis describes the research and development of novel …