Biomedical Engineering and Bioengineering Commons^™

Passive Acoustic Emissions Monitoring Of Fluidized Bed Pellet Coating, Taylor Sheahan

Electronic Thesis and Dissertation Repository

Passive acoustic emissions were assessed for their potential as a non-invasive monitoring tool for the coating of pellets in a fluidized bed. Pharmaceutical pellets are small spherical particles that contain an active ingredient. They are film coated for the purpose of modified drug release and packed into capsules as a multiple unit dosage form. A more reliable monitoring and control method is desired to ensure the appropriate drug release profile is achieved by minimizing variations within and between coated pellets.

Microphones attached to the exterior of a conical top spray fluidized bed measured acoustic emissions produced from the coating process. …