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Engineering Periodontal Tissue Regeneration With The Use Of A Novel Periostin Electrospun Scaffold, Kendal I. Creber

Electronic Thesis and Dissertation Repository

Clinical therapies for the treatment of periodontitis are unable to reproducibly stimulate regeneration of the periodontium. We assessed the use of a novel electrospun type I collagen scaffold containing recombinant periostin to stimulate regeneration of the periodontal ligament (PDL) and bone. Human PDL cells demonstrated the ability to form a mineralized matrix in vitro and reduced osteogenic potential with increased donor age. In vitro analysis indicated scaffolds were biocompatible, however, periostin did not significantly influence adhesion or growth. In the healing of fenestration defects in rats, type I collagen scaffolds (with and without periostin) initially delayed cell infiltration and increased …