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Biomedical Engineering and Bioengineering Commons

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Full-Text Articles in Biomedical Engineering and Bioengineering

The Influence Of Processing And Additives On Cellulose Nanofiber Properties For Orthopedic Application, Mitchell P. Chesley Aug 2022

The Influence Of Processing And Additives On Cellulose Nanofiber Properties For Orthopedic Application, Mitchell P. Chesley

Electronic Theses and Dissertations

Current orthopedics are separated into three different classes of materials, metals, polymers, and ceramics. While these devices have had success throughout the years they are not without their faults. Metallic devices for example are usually extraordinarily stiff when compared with the surrounding bone. This difference in stiffness induces localized stress-shielding promoting cortical atrophy, which can lead to osteoporosis. Polymers while having the capacity of being biodegradable and bioabsorbable also have the potential to incite localized demineralization and weakness in surrounding bone. A result of breakdown byproducts not efficiently being evacuated from the area, which additionally acts as catalysts expediating the …


Developing And Characterizing A Novel Tempo Cnf Hydrogel Adjuvant And Delivery System For Aquatic Vaccines, Kora Kukk Aug 2022

Developing And Characterizing A Novel Tempo Cnf Hydrogel Adjuvant And Delivery System For Aquatic Vaccines, Kora Kukk

Electronic Theses and Dissertations

Aquaculture is a large part of the food production sector which is greatly expanding. One of the largest losses in aquaculture is due to pathogens. Current solutions for protecting farmed finfish from pathogens can be very expensive with variable efficiency. Current disease prevention strategies include vaccination. Types of vaccines include immersion vaccines, feed vaccines, and injectable vaccines. The most popular solution is oil-based injectable vaccines due to its protection. However, the oil-based adjuvant used in most of these formulations causes adverse reactions in the fish including reduced growth. These vaccines require multiple administrations throughout the fish’s lifetime causing unwanted handling …


Continuous, Non-Destructive Detection Of Surface Bacterial Growth With Bioinspired Vascularized Polymers, Brandon Dixon Aug 2022

Continuous, Non-Destructive Detection Of Surface Bacterial Growth With Bioinspired Vascularized Polymers, Brandon Dixon

Electronic Theses and Dissertations

Reducing or eliminating bacteria on surfaces is vital for medical devices, drinking water quality, and industrial processes. Evaluating surface bacterial growth at buried interfaces can be problematic due to the time-consuming disassembly process required for obtaining standard surface samples. In this work, a continuous, non-destructive, and reusable method was developed to detect surface bacterial growth at buried interfaces. Inspired by vascular systems in nature that permit chemical communication between the surface and underlying tissues of an organism, bacterial-specific signals diffusing from cells on the surface were detected in channels filled with an inert carrier fluid embedded in a polymer matrix. …