Biomedical Engineering and Bioengineering Commons^™

Surface-Eroding Drug Delivery Films For Sequential And/Or Intermittent Release Of Psychoactive Drugs, Jason Price

Honors Theses

ABSTRACT JASON BLAKE PRICE: Surface-Eroding Drug Delivery Films for Sequential and/or

Intermittent Release of Psychoactive Drugs For patients with psychiatric diseases, adherence to medication schedules, medication

errors, and abuse are common issues. Promising new forms of therapy for these patients, such as micro-dosed lysergic acid diethylamide (LSD), where patients receive 10-20% of a full dose every third day, present further drug delivery challenges. Sequential or intermittent release of drugs from an implanted device could ensure long-term drug compliance, automate drug dosing during the life of the implant, and eliminate potential for abuse and medication errors. To this end, we generated …

Hydrolytic Degradation Study Of Polyphosphazene-Plga Blends, Riley Blumenfield

Honors Scholar Theses

The synthesis and in vitro degradation analysis of thin films of poly[(glycineethylglycinato)₇₅(phenylphenoxy)₂₅phosphazene]
(PNGEG₇₅PhPh₂₅) and poly[(ethylphenylalanato)₂₅(glycine-
ethylglycinato)₇₅phosphazene] (PNEPA₂₅GEG₇₅) blended with poly(lactic-co-glycolic acid) (PLGA) was conducted to determine the blends’ potential for use as scaffolding materials for tissue regeneration applications. The samples were synthesized with glycylglycine ethyl ester (GEG) acting as the primary substituent side group, with cosubstitution by phenylphenol (PhPh) and phenylalanine ethyl ester (EPA) to make the final product [1]. Blends of 25% polyphosphazene, 75% PLGA and 50% polyphosphazene, 50% PLGA were …

Production Of Lignin-Based Phenolic Resins Using De-Polymerized Kraft Lignin And Process Optimization, Homaira Siddiqui

Electronic Thesis and Dissertation Repository

Commercialization of Lignin-based phenol formaldehyde resins (LPF) has been limited due to the increase in curing temperatures and decrease in adhesive strength of LPF compared to conventional phenolic resins. Lignin depolymerization can increase the reactivity of lignin; however, the effect of lignin molecular weight on curing performance of LPF resins has yet to be investigated. This research work examined the optimization of synthesis parameters including percent substitution of phenol with lignin, formaldehyde- to-phenol ratio (F/P), and Mw of lignin to reduce the curing temperature and increase the adhesive strength of LPF. DSC analysis indicated that lignin with Mw ~1200g/mol resulted …