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Biomedical Engineering and Bioengineering Commons™
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- Osteogenesis (2)
- 13-93 bioactive glass (1)
- 3D printing (1)
- <p>Bone regeneration<br />Tissue scaffolds<br />Bioactive compounds<br />Glass in medicine<br />Three-dimensional printing</p> (1)
- Angiogenesis (1)
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- BMP-2 (1)
- BMP2 (1)
- Bio-design (1)
- Bio-fabrication (1)
- Calvarial Defect (1)
- Collagen (1)
- Collagen binding peptides (1)
- Extracellular matrix mimics (1)
- Fibronectin (1)
- Fibronectin binding peptides (1)
- Hydroxyapatite (1)
- In vivo (1)
- Material ecology (1)
- Mycelium (1)
- Phage Display (1)
- Regenerative design (1)
- Relaxin (1)
Articles 1 - 5 of 5
Full-Text Articles in Biomedical Engineering and Bioengineering
Fungi In Flux | Designing Regenerative Materials And Products With Mycelium, Arvind Bhallamudi
Fungi In Flux | Designing Regenerative Materials And Products With Mycelium, Arvind Bhallamudi
Masters Theses
As the world grapples with the escalating crisis of climate threats and environmental degradation, this research delves into the synergistic potential of design and biology, developing safe and sustainable materials for applications in prototyping, furniture and interior design. Harnessing the power of a unique organism - fungi, the study proposes an accessible, efficient, and resilient material resource system. It utilizes local waste streams and mycelium (the vegetative part of fungi) to grow functional structures. An experimental and small-scale protocol is modeled by testing bio-fabrication and bio-printing methods. The composites' performance qualities and characteristics are evaluated through mechanical testing and a …
In Vitro And In Vivo Response To A Novel Borophosphate Bioactive Glass, Nada Abokefa
In Vitro And In Vivo Response To A Novel Borophosphate Bioactive Glass, Nada Abokefa
Masters Theses
"Bioactive glasses have been widely used in several biomedical and tissue engineering applications since the late 1960s. Numerous families of bioactive glasses have emerged over the years, with each having its own advantage and disadvantage. One concern common to all families is that most bioactive glasses create a basic or acidic environment when degraded and, therefore, are toxic for cells. Recently, there has been an increased interest in borophosphate bioactive glass (BPBGs) because of their neutral pH, release of therapeutic ions, and biodegradable properties. Despite the growing interest, there is little reported on the bioactivity of BPBGs. The biological effects …
Combination Of Bmp-2 And Relaxin To Induce Osteogenesis In Vivo, Sahitya Injamuri
Combination Of Bmp-2 And Relaxin To Induce Osteogenesis In Vivo, Sahitya Injamuri
Masters Theses
"Bone grafts are a common procedure for treating craniofacial injuries such as trauma, surgery, and reconstruction. Autografts and allografts have limitations which encourages the use of synthetic bone grafts. While synthetic bone grafts, such as hydroxyapatite (HA) microspheres, are advantageous for their cost and reproducibility, they lack the cells and growth factors needed for proper osteoinduction. Bone morphogenetic protein-2 (BMP-2) has been shown to increase the osteoinduction of grafts but the effective dose is above physiological levels and causes undesired effects on the body. Relaxin has been shown to enhance BMP-2's ability to induce bone formation in vitro and thus …
Promoting Extracellular Matrix Crosslinking In Synthetic Hydrogels, Marcos M. Manganare
Promoting Extracellular Matrix Crosslinking In Synthetic Hydrogels, Marcos M. Manganare
Masters Theses
The extracellular matrix (ECM) provides mechanical and biochemical support to tissues and cells. It is crucial for cell attachment, differentiation, and migration, as well as for ailment-associated processes such as angiogenesis, metastases and cancer development. An approach to study these phenomena is through emulation of the ECM by synthetic gels constructed of natural polymers, such as collagen and fibronectin, or simple but tunable materials such as poly(ethylene glycol) (PEG) crosslinked with short peptide sequences susceptible to digestion by metalloproteases and cell-binding domains. Our lab uses PEG gels to study cell behavior in three dimensions (3D). Although this system fosters cell …
Healing Of Bone Defects In A Rodent Calvarial Defect Model Using Strong Porous Bioactive Glass (13-93) Scaffolds, Yinan Lin
Masters Theses
"The main objective of this project was to evaluate the capacity of strong porous silicate (13-93) bioactive glass scaffolds prepared by a robocasting technique to regenerate bone and stimulate angiogenesis in a rat calvarial defect model. The scaffolds were created with the same grid-like microstructure but in a variety of formulations: (i) as-fabricated, (ii) pretreated in an aqueous phosphate solution to convert the glass surface to hydroxyapatite, (iii) loaded with bone morphogenetic protein-2 (BMP2) (1 µg per scaffold), and (iv) doped with copper (0.4-2.0 wt. % CuO). When compared to the as-fabricated scaffolds, the pretreated scaffolds enhanced bone regeneration at …