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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
A Model For A Model: Pressure Jackets On Nude Mice With Implants Of Hypertrophic Scars, C. Ward Kischer, Jana Pindur
A Model For A Model: Pressure Jackets On Nude Mice With Implants Of Hypertrophic Scars, C. Ward Kischer, Jana Pindur
Cells and Materials
The hypertrophic scar, a consequence of deep surface injury, is peculiar to humankind. Subcutaneous implants of these tissues in nude mice provide a quasi - animal model for experimental use. An efficacious treatment to promote acceleration of maturation of the hypertrophic scar is controlled topical pressure produced by flexible dacron fabric wraps. Implants in the nude mouse provide a model for study of the effects of pressure. Preliminary results indicate that those implants in nude mice, responding favorably to pressure jackets, show changes consistent with those previously obtained in human studies. The collagen matrix shows reduced density and parallel layering …
Peripheral Nerve Regeneration Within Tubular Prosthesis: Effects Of Laminin And Collagen Matrices On Cellular Ingrowth, Ivar J. Kljavin, Roger D. Madison
Peripheral Nerve Regeneration Within Tubular Prosthesis: Effects Of Laminin And Collagen Matrices On Cellular Ingrowth, Ivar J. Kljavin, Roger D. Madison
Cells and Materials
Bridging a severed peripheral nerve with a tubular conduit, "entubulation repair" , allows manipulation of the microenvironment encountered by regenerating axons. In the present study, we placed the ends of severed mouse sciatic nerves into nonpermeable Tygon tubes to bridge a 4 mm nerve gap. The tube lumen was filled with either a collagen or laminin matrix. The matrices formed a stable 3-D structure connecting both proximal and distal stumps, and provided a scaffolding for the regenerating axons and their supporting cells. We examined with scanning electron microscopy (SEM), transmission electron microscopy (TEM) and light microscopy, the initial events of …