Open Access. Powered by Scholars. Published by Universities.®
Biomedical Engineering and Bioengineering Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Biomedical Engineering and Bioengineering
Functional And Dysrhythmic Slow Waves In The Stomach - An In Silico Study, Md Ashfaq Ahmed
Functional And Dysrhythmic Slow Waves In The Stomach - An In Silico Study, Md Ashfaq Ahmed
FIU Electronic Theses and Dissertations
Peristalsis, the coordinated contraction and relaxation of the muscles of the stomach, is important for normal gastric motility and is impaired in motility disorders. Coordinated electrical depolarizations that originate and propagate within a mutually coupled network of interstitial cells of Cajal (ICC) and smooth muscle cells of the stomach wall as a slow-wave, underly peristalsis. Normally, the gastric slow-wave (GSW) oscillates with a single period and uniform rostro-caudal lag, exhibiting network entrainment. Loss of entrainment in the coupled network and the resulting impairment in slow-wave propagation is associated with various gastric motility disorders. Our study provides an enhanced understanding of …