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Biomedical Engineering and Bioengineering Commons™
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- Confocal microscopy (4)
- Epidermis - Imaging (4)
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- Confocal Microscope (2)
- Epidermis (2)
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- FDTD (2)
- In vivo (2)
- Inhomogeneity (2)
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- Skin (2)
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- Breast cancer (1)
- Breast--Radiography (1)
- Confocal Reflectance Microscope (1)
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- MRNA (1)
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- Optical prisms (1)
- Optoacoustics (1)
- Parenchyma (1)
- Plasmon (1)
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Articles 1 - 8 of 8
Full-Text Articles in Biomedical Engineering and Bioengineering
Correct Spectral Conversion Between Surface‐Enhanced Raman And Plasmon Resonance Scattering From Nanoparticle Dimers For Single‐Molecule Detection, Kyuwan Lee
Kyuwan Lee
Simultaneous measurement of surface-enhanced Raman scattering (SERS) and localized surface plasmon resonance (LSPR) in nanoparticle dimers presents outstanding opportunities in molecular identification and in the elucidation of physical properties, such as the size, distance, and deformation of target species. SERS–LSPR instrumentation exists and has been used under limited conditions, but the extraction of SERS and LSPR readouts from a single measurement is still a challenge. Herein, the extraction of LSPR spectra from SERS signals is reported and a tool for measuring the interparticle distance from Raman enhancement data by the standardization of the SERS signal is proposed. The SERS nanoruler …
Hemodynamically Constrained Dynamic Diffuse Optical Tomography Under Mammographic Compression, Eleonora Vidolova, Dana H. Brooks, Eric L. Miller, Stefan Carp, David A. Boas
Hemodynamically Constrained Dynamic Diffuse Optical Tomography Under Mammographic Compression, Eleonora Vidolova, Dana H. Brooks, Eric L. Miller, Stefan Carp, David A. Boas
Dana Brooks
This poster considers these points: DOT taken along x-ray mammogram provide valuable functional information, X-ray mammography only gives structural information hard to distinguish between benign and malignant masses, Oxygen consumption (OC) and blood flow (F) contrasts observed between malignant and normal tissue[3, 4], Blood flow, oxygen saturation(SO2), water and lipid distributions could specify the degree of malignancy of a tumor, Physiological changes in the breast due to mammographic compression are significant and should be taken into account[2].
Fdtd Simulation Of A Confocal Microscope Using A Theta Line Scan, Blair Simon, Charles Dimarzio, Milind Rajadhyaksha, Carey Rappaport
Fdtd Simulation Of A Confocal Microscope Using A Theta Line Scan, Blair Simon, Charles Dimarzio, Milind Rajadhyaksha, Carey Rappaport
Carey Rappaport
We describe a 2-D computational model of the optical propagation in human skin from a confocal reflectance theta microscope. As an effect of decreasing the size of the microscope so that it is more clinically useful, the usual point source and detector with a raster scan is changed to a line source with a 1-D array detector. Because there is only one dimension of scanning, the microscope is confocal in one direction, but not in the other, however, this results in additional localized decreases in signal. We hypothesize that these result from the interaction of the bi-static imaging configuration with …
Field Programmable Gate Arrays To Accelerate Sub-Surface Imaging Problems, Miriam Leeser
Field Programmable Gate Arrays To Accelerate Sub-Surface Imaging Problems, Miriam Leeser
Miriam Leeser
No abstract provided.
Fdtd Simulation Of A Confocal Microscope Using A Theta Line Scan, Blair Simon, Charles Dimarzio, Milind Rajadhyaksha, Carey Rappaport
Fdtd Simulation Of A Confocal Microscope Using A Theta Line Scan, Blair Simon, Charles Dimarzio, Milind Rajadhyaksha, Carey Rappaport
Charles A. DiMarzio
We describe a 2-D computational model of the optical propagation in human skin from a confocal reflectance theta microscope. As an effect of decreasing the size of the microscope so that it is more clinically useful, the usual point source and detector with a raster scan is changed to a line source with a 1-D array detector. Because there is only one dimension of scanning, the microscope is confocal in one direction, but not in the other, however, this results in additional localized decreases in signal. We hypothesize that these result from the interaction of the bi-static imaging configuration with …
Photo-Thermal Coherent Confocal Microscope, Sean Sullivan, Charles Dimarzio
Photo-Thermal Coherent Confocal Microscope, Sean Sullivan, Charles Dimarzio
Charles A. DiMarzio
Confocal microscopy has been shown to be useful in imaging skin slightly below the junction of the dermis and epidermis. However, the depth of imaging is a significant limitation. We present a novel concept designed both to improve the depth of penetration and to increase the information content of images obtained with a reflectance confocal microscope. Using an approach similar to optoacoustics, we plan to explore the use of laser heating to generate tissue expansion, which will be measured by the microscope. The microscope will incorporate a pulsed heating laser along the same optical path as the imaging laser in …
Compact Dual Wedge Point Scanning Confocal Reflectance Microscope, William C. Warger Ii, Stephen A. Guerrera, Charles A. Dimarzio
Compact Dual Wedge Point Scanning Confocal Reflectance Microscope, William C. Warger Ii, Stephen A. Guerrera, Charles A. Dimarzio
Charles A. DiMarzio
Confocal reflectance microscopy has been shown to provide optical sectioning and resolution sufficient to provide useful information about skin to a depth below the epidermis. However, existing instruments are large and expensive, because of the need for fast twodimensional scanning in the pupil, and the associated relay optics. A more compact scanning system could lead to an affordable hand-held instrument for in vivo imaging. Several approaches are being considered with different advantages and disadvantages. Here we report one approach that incorporates a dual-wedge scanner within a point-scanning configuration. The dual-wedge scanner is implemented by replacing the two scanning mirrors and …
Simultaneous Estimation And Segmentation Of T1 Map For Breast Parenchyma Measurement, Ye Xing, Yangming Ou, Sarah Englander, Mitchell D. Schnall, Dinggang Shen
Simultaneous Estimation And Segmentation Of T1 Map For Breast Parenchyma Measurement, Ye Xing, Yangming Ou, Sarah Englander, Mitchell D. Schnall, Dinggang Shen
Sarah Englander
Breast density has been shown to be an independent risk factor for breast cancer. In order to segment breast parenchyma, which has been proposed as a biomarker of breast cancer risk, we present an integrated algorithm for simultaneous T1 map estimation and segmentation, using a series of magnetic resonance (MR) breast images. The advantage of using this algorithm is that the step of T1 map estimation (E-Step) and the step of T1 map based tissue segmentation (S-Step) can benefit each other. Since the estimated T1 map can be noisy due to the complexity of T1 estimation method, the tentative tissue …