Biomedical Engineering and Bioengineering Commons^™

Correlation Of Acute Radiation Dermatitis To Tissue Oxygenation In Radiation Therapy Treated Breast Cancer Subjects, Edwin Alexander Robledo

FIU Electronic Theses and Dissertations

Over 95% of radiation therapy (RT) treated breast cancer subjects undergo an adverse skin reaction known as radiation dermatitis (RD). Assessment of severity or grading of RD is clinically visual and hence subjective. Our objective is to determine sub-clinical tissue oxygenation (StO₂) changes in response to RT treatment in breast cancer subjects using near-infrared spectroscopic imaging and correlate these changes to RD grading. A WIRB approved 6-8 week longitudinal pilot study was carried out on 10 RT-treated subjects at Miami Cancer Institute. Significant changes (p < 0.05) in StO₂ of irradiated and contralateral chest wall and axilla regions with weeks of …