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On The Development Of A Dynamic Contrast-Enhanced Near-Infrared Technique To Measure Cerebral Blood Flow In The Neurocritical Care Unit, Jonathan T. Elliott
On The Development Of A Dynamic Contrast-Enhanced Near-Infrared Technique To Measure Cerebral Blood Flow In The Neurocritical Care Unit, Jonathan T. Elliott
Electronic Thesis and Dissertation Repository
A dynamic contrast-enhanced (DCE) near-infrared (NIR) method to measure cerebral blood flow (CBF) in the neurocritical care unit (NCU) is described. A primary concern in managing patients with acquired brain injury (ABI) is onset of delayed ischemic injury (DII) caused by complications during the days to weeks following the initial insult, resulting in reduced CBF and impaired oxygen delivery.
The development of a safe, portable, and quantitative DCE-NIR method for measuring CBF in NCU patients is addressed by focusing on four main areas: designing a clinically compatible instrument, developing an appropriate analytical framework, creating a relevant ABI animal model, and …