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Biomedical Engineering and Bioengineering Commons™
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- Biomedical (2)
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Articles 1 - 7 of 7
Full-Text Articles in Biomedical Engineering and Bioengineering
Characterization Of Mammographic Dense Tissue Sub-Types Using Classification Algorithms On Metric Space Technique Output Functions, Madison Raza
Electronic Theses and Dissertations
In recent years breast cancer has become the leading cause of global cancer incidence. One of the most common forms of screening is through the use of digital x-ray screening mammography. Risk assessment models which help predict a patient’s risk of developing breast cancer rely mainly on patient history and qualitative breast density assessment from screening. The 2D wavelet transform maxima modulus (2D WTMM) method uses a sliding window approach to quantify the spatial organization of underlying mammographic tissue according to Hurst- exponent ranges (H) as fatty (H ≤ 0.45), healthy dense (H ≥ 0.55) and …
Using Shg Directionality To Characterize Collagen Alteration In Breast Cancer Tumor Microenvironment And Its Prognostic Applications, Betelhem Solomon Abay
Using Shg Directionality To Characterize Collagen Alteration In Breast Cancer Tumor Microenvironment And Its Prognostic Applications, Betelhem Solomon Abay
Electronic Theses and Dissertations
Although breast cancer is a growing health concern worldwide, the challenge to minimize mortality rate partly comes from the heterogeneity in its pathological characteristics. The tumor microenvironment is a complex hub of signaling cascades that plays a key role for the progression of cancer to develop to metastatic stage. The extracellular matrix (ECM), as a major component of the tumor microenvironment, contains signatures that have cues to understand tumor progression. Here, the unique microstructural collagen alterations specific to reactive stromal/tumor cell interactions and interactions of reactive stromal fibroblasts with different tumor cell types MCF7A and MDA-MB-231 were investigated. Early alterations …
Wavelet-Based Automatic Breast Segmentation For Mammograms, Basel White
Wavelet-Based Automatic Breast Segmentation For Mammograms, Basel White
Honors College
As part of a first of its kind analysis of longitudinal mammograms, there are thousands of mammograms that need to be analyzed computationally. As a pre- processing step, each mammogram needs to be converted into a binary (black or white) spatial representation in order to delineate breast tissue from the pectoral muscle and image background, which is called a mammographic mask. The current methodology for completing this task is for a lab member to manually trace the outline of the breast, which takes approximately three minutes per mammogram. Thus, reducing the time cost and human subjectivity when completing this task …
Design, Construction And Application Of A Home-Built, Two-Photon Microscope, William P. Breeding
Design, Construction And Application Of A Home-Built, Two-Photon Microscope, William P. Breeding
Electronic Theses and Dissertations
Two-photon microscopy (TPM) is a powerful, versatile imaging modality for the study of biological systems. This thesis overviews the relevant physics involved in TPM, design considerations and process of constructing a home-built, two-photon microscope, and provides a set of procedures to operate the system. Furthermore, this work explores several applications of TPM through the study of single-cell metabolism and imaging the cellular-material interface. Explored in particular depth was the imaging of cellulose nanofiber (CNF) materials, with the goal of understanding the three-dimensional nature of fibroblast cell growth when embedded within the materials. This work uncovered several optical properties of CNF, …
Development Of Spectroscopic Methods For Dynamic Cellular Level Study Of Biochemical Kinetics And Disease Progression, Anna M. Sitarski
Development Of Spectroscopic Methods For Dynamic Cellular Level Study Of Biochemical Kinetics And Disease Progression, Anna M. Sitarski
Electronic Theses and Dissertations
One of the current fundamental objectives in biomedical research is understanding molecular and cellular mechanisms of disease progression. Recent work in genetics support the stochastic nature of disease progression on the single cell level. For example, recent work has demonstrated that cancer as a disease state is reached after the accumulation of damages that result in genetic errors. Other diseases like Huntingtons, Parkinsons, Alzheimers, cardiovascular disease are developed over time and their cellular mechanisms of disease transition are largely unknown. Modern techniques of disease characterization are perturbative, invasive and fully destructive to biological samples. Many methods need a probe or …
A Multi-Channel 3d-Printed Bioreactor For Evaluation Of Growth And Production In The Microalga Dunaliella Sp, Cristian A. Cox
A Multi-Channel 3d-Printed Bioreactor For Evaluation Of Growth And Production In The Microalga Dunaliella Sp, Cristian A. Cox
Electronic Theses and Dissertations
We explored the capabilities of additive manufacturing using a photo-cured jetted material 3D printer to manufacture a milli-microfluidic device with direct application in microalgae Dunaliella sp growth and intracellular compounds biosynthesis tests. A continuous microbioreactor for microalgae culture was CAD designed and successfully built in 1 hour and 49 minutes using black photopolymer cured by UV and a support material. The microreactor was made up of 2 parts including the bioreactor itself and a microchannel network for culture media fluids and microalgae. Both parts were assembled to form a single unit. Additional optical and auxiliar components were added. An external …
Cdi-Type Ii: Collaborative Research: Cyber Enhancement Of Spatial Cognition For The Visually Impaired, Nicholas Giudice
Cdi-Type Ii: Collaborative Research: Cyber Enhancement Of Spatial Cognition For The Visually Impaired, Nicholas Giudice
University of Maine Office of Research Administration: Grant Reports
Wayfinding is an essential capability for any person who wishes to have an independent life-style. It requires successful execution of several tasks including navigation and object and place recognition, all of which necessitate accurate assessment of the surrounding environment. For a visually-impaired person these tasks may be exceedingly difficult to accomplish and there are risks associated with failure in any of these. Guide dogs and white canes are widely used for the purpose of navigation and environment sensing, respectively. The former, however, has costly and often prohibitive training requirements, while the latter can only provide cues about obstacles in one's …