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Full-Text Articles in Biomedical Engineering and Bioengineering

Hemodynamically Constrained Dynamic Diffuse Optical Tomography Under Mammographic Compression, Eleonora Vidolova, Dana H. Brooks, Eric L. Miller, Stefan Carp, David A. Boas Apr 2012

Hemodynamically Constrained Dynamic Diffuse Optical Tomography Under Mammographic Compression, Eleonora Vidolova, Dana H. Brooks, Eric L. Miller, Stefan Carp, David A. Boas

Dana Brooks

This poster considers these points: DOT taken along x-ray mammogram provide valuable functional information, X-ray mammography only gives structural information hard to distinguish between benign and malignant masses, Oxygen consumption (OC) and blood flow (F) contrasts observed between malignant and normal tissue[3, 4], Blood flow, oxygen saturation(SO2), water and lipid distributions could specify the degree of malignancy of a tumor, Physiological changes in the breast due to mammographic compression are significant and should be taken into account[2].


Fdtd Simulation Of A Confocal Microscope Using A Theta Line Scan, Blair Simon, Charles Dimarzio, Milind Rajadhyaksha, Carey Rappaport Apr 2012

Fdtd Simulation Of A Confocal Microscope Using A Theta Line Scan, Blair Simon, Charles Dimarzio, Milind Rajadhyaksha, Carey Rappaport

Carey Rappaport

We describe a 2-D computational model of the optical propagation in human skin from a confocal reflectance theta microscope. As an effect of decreasing the size of the microscope so that it is more clinically useful, the usual point source and detector with a raster scan is changed to a line source with a 1-D array detector. Because there is only one dimension of scanning, the microscope is confocal in one direction, but not in the other, however, this results in additional localized decreases in signal. We hypothesize that these result from the interaction of the bi-static imaging configuration with …


Field Programmable Gate Arrays To Accelerate Sub-Surface Imaging Problems, Miriam Leeser Apr 2012

Field Programmable Gate Arrays To Accelerate Sub-Surface Imaging Problems, Miriam Leeser

Miriam Leeser

No abstract provided.


Fdtd Simulation Of A Confocal Microscope Using A Theta Line Scan, Blair Simon, Charles Dimarzio, Milind Rajadhyaksha, Carey Rappaport Apr 2012

Fdtd Simulation Of A Confocal Microscope Using A Theta Line Scan, Blair Simon, Charles Dimarzio, Milind Rajadhyaksha, Carey Rappaport

Charles A. DiMarzio

We describe a 2-D computational model of the optical propagation in human skin from a confocal reflectance theta microscope. As an effect of decreasing the size of the microscope so that it is more clinically useful, the usual point source and detector with a raster scan is changed to a line source with a 1-D array detector. Because there is only one dimension of scanning, the microscope is confocal in one direction, but not in the other, however, this results in additional localized decreases in signal. We hypothesize that these result from the interaction of the bi-static imaging configuration with …


Compact Dual Wedge Point Scanning Confocal Reflectance Microscope, William C. Warger Ii, Stephen A. Guerrera, Charles A. Dimarzio Apr 2012

Compact Dual Wedge Point Scanning Confocal Reflectance Microscope, William C. Warger Ii, Stephen A. Guerrera, Charles A. Dimarzio

Charles A. DiMarzio

Confocal reflectance microscopy has been shown to provide optical sectioning and resolution sufficient to provide useful information about skin to a depth below the epidermis. However, existing instruments are large and expensive, because of the need for fast twodimensional scanning in the pupil, and the associated relay optics. A more compact scanning system could lead to an affordable hand-held instrument for in vivo imaging. Several approaches are being considered with different advantages and disadvantages. Here we report one approach that incorporates a dual-wedge scanner within a point-scanning configuration. The dual-wedge scanner is implemented by replacing the two scanning mirrors and …


Simultaneous Estimation And Segmentation Of T1 Map For Breast Parenchyma Measurement, Ye Xing, Yangming Ou, Sarah Englander, Mitchell D. Schnall, Dinggang Shen Feb 2012

Simultaneous Estimation And Segmentation Of T1 Map For Breast Parenchyma Measurement, Ye Xing, Yangming Ou, Sarah Englander, Mitchell D. Schnall, Dinggang Shen

Sarah Englander

Breast density has been shown to be an independent risk factor for breast cancer. In order to segment breast parenchyma, which has been proposed as a biomarker of breast cancer risk, we present an integrated algorithm for simultaneous T1 map estimation and segmentation, using a series of magnetic resonance (MR) breast images. The advantage of using this algorithm is that the step of T1 map estimation (E-Step) and the step of T1 map based tissue segmentation (S-Step) can benefit each other. Since the estimated T1 map can be noisy due to the complexity of T1 estimation method, the tentative tissue …