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Full-Text Articles in Biomedical Engineering and Bioengineering
Development Of Novel Models To Study Deep Brain Effects Of Cortical Transcranial Magnetic Stimulation, Farheen Syeda
Development Of Novel Models To Study Deep Brain Effects Of Cortical Transcranial Magnetic Stimulation, Farheen Syeda
Theses and Dissertations
Neurological disorders require varying types and degrees of treatments depending on the symptoms and underlying causes of the disease. Patients suffering from medication-refractory symptoms often undergo further treatment in the form of brain stimulation, e.g. electroconvulsive therapy (ECT), transcranial direct current stimulation (tDCS), deep brain stimulation (DBS), or transcranial magnetic stimulation (TMS). These treatments are popular and have been shown to relieve various symptoms for patients with neurological conditions. However, the underlying effects of the stimulation, and subsequently the causes of symptom-relief, are not very well understood. In particular, TMS is a non-invasive brain stimulation therapy which uses time-varying magnetic …
Identification And Retraining Of Sensorimotor Deficits To Reduce Intention Tremor In Multiple Sclerosis, Megan Heenan
Identification And Retraining Of Sensorimotor Deficits To Reduce Intention Tremor In Multiple Sclerosis, Megan Heenan
Dissertations (1934 -)
Multiple sclerosis (MS) affects approximately 1 in 1000 Americans and is a significant cause of disability in the United States. One significant contributor to disability in MS is intention tremor, which manifests as an oscillation about the endpoint of a goal-directed movement. A major challenge of treating intention tremor is that the underlying causes of tremor in MS are unknown. In this study, we describe a systems-level computational model and an experimental technique that parameterizes subject-specific deficits in sensory feedback control during goal-directed movements. We used this approach to characterize sensorimotor control and examine how sensory and motor processes are …