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Understanding The Underlying Mechanism Of Age-Related Underactive Bladder And Proposing A Treatment Option To Mitigate Its Symptoms, Arezoo Gerami Pour
Understanding The Underlying Mechanism Of Age-Related Underactive Bladder And Proposing A Treatment Option To Mitigate Its Symptoms, Arezoo Gerami Pour
FIU Electronic Theses and Dissertations
The prevalence of underactive bladder (UAB) increases with age, suggesting a link between age-related processes and lower urinary tract (LUT) symptoms; however, the underlying mechanisms of age-related UAB are poorly understood. UAB is characterized by inefficient voiding and bladder overdistension. Due to the unknown etiology, current therapeutic options are insufficient. Thus, a detailed understanding of its mechanism will facilitate the discovery of new treatments.
In Aim 1, we investigated the relationship between age and systems-level function of the LUT reflexes in three age groups of rats, testing the hypothesis that aging causes voiding reflexes to weaken. We systematically investigated the …