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Biomedical Engineering and Bioengineering Commons™
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Articles 1 - 3 of 3
Full-Text Articles in Biomedical Engineering and Bioengineering
Poly(Ester Amide) And Poly(Ethyl Glyoxylate) Nanoparticles For Controlled Drug Release, Amira Mohamed Moustafa
Poly(Ester Amide) And Poly(Ethyl Glyoxylate) Nanoparticles For Controlled Drug Release, Amira Mohamed Moustafa
Electronic Thesis and Dissertation Repository
The objective of this research was to develop polymeric nanoparticles (NPs) having improved drug release properties for drug delivery. Poly(ester amide)s (PEAs) are promising biodegradable polymers. PEA NPs were prepared via emulsification-evaporation and salting-out methods and optimized through by varying different processing parameters. Polymer-model drug conjugates based on PEAs containing L-aspartic acid and rhodamine B were synthesized and used for NP preparation. Release behavior was studied and compared to a control system with physically encapsulated rhodamine B. It was shown that the release of rhodamine B from the covalent system did not show the burst effect and exhibited a slower …
Drug Delivery To The Respiratory Tract Using Dry Powder Inhalers, Doaa M.R. Mossaad
Drug Delivery To The Respiratory Tract Using Dry Powder Inhalers, Doaa M.R. Mossaad
Electronic Thesis and Dissertation Repository
Aerosols are an effective method to deliver therapeutic agents to the respiratory tract. Among aerosol generation systems, dry powder inhales have been attractive area of research for both local and systemic delivery of drugs. The challenge of any inhalation delivery system is to generate particles with an adequate range of particle sizes. In order to advance powder aerosol technologies, researchers have recognized the importance of investigating determinants affecting powder dispersion. The effect of particles’ surface characteristics, inhalation airflow rate, inhalation device, and development of an effective drug-carrier system are some of the fundamental areas that have been under investigation.
The …
Surface Functionalization And Bioconjugation Of Nanoparticles For Biomedical Applications, Longyan Chen
Surface Functionalization And Bioconjugation Of Nanoparticles For Biomedical Applications, Longyan Chen
Electronic Thesis and Dissertation Repository
Colloidal inorganic nanoparticles (NPs) have been attracting considerable interest in biomedicine, from drug and gene delivery to imaging, sensing and diagnostics. It is essential to modify the surface of nanoparticles to have enhanced biocompatibility and functionality for the in vitro and in vivo applications, especially in delivering locally and recognizing biomolecules. Herein, the goal of this research work is to develop advanced NPs with well-tailored surface functionalities and/or bio-functionality for the applications in cell tracking and analytes detection.
In the first project, quantum dots incorporating with gelatin nanoparticles (QDs-GNPs) have been developed for bioimaging applications. Two different approaches have been …