Engineering Commons^™

Tau Kinetics In Alzheimer's Disease, Daniel B. Hier, Sima Azizi, Matthew S. Thimgan, Donald C. Wunsch

Chemistry Faculty Research & Creative Works

The Cytoskeletal Protein Tau is Implicated in the Pathogenesis of Alzheimer's Disease Which is Characterized by Intra-Neuronal Neurofibrillary Tangles Containing Abnormally Phosphorylated Insoluble Tau. Levels of Soluble Tau Are Elevated in the Brain, the CSF, and the Plasma of Patients with Alzheimer's Disease. to Better Understand the Causes of These Elevated Levels of Tau, We Propose a Three-Compartment Kinetic Model (Brain, CSF, and Plasma). the Model Assumes that the Synthesis of Tau Follows Zero-Order Kinetics (Uncorrelated with Compartmental Tau Levels) and that the Release, Absorption, and Clearance of Tau is Governed by First-Order Kinetics (Linearly Related to Compartmental Tau Levels). …

Cardiovascular Surgery Practice Remodel: Increasing Job Satisfaction And Reducing Turnover Rates Of Advanced Practice Providers, Christian Brooks

Doctor of Nursing Practice Scholarly Project

Cardiovascular Surgery Practice Remodel: Increasing Job Satisfaction and Reducing Turnover Rates of Advanced Practice Providers

Background: The CVS practice in a Midwestern state had a shift in morale and job satisfaction in their advanced practice providers (APPs). This shift lead to the high turnover rate of 35% in 2018. In an effort to bring a halt to the high turnover rate, and to continue the excellent patient care for which the hospital is known, hospital administration became involved and set up a committee to guide the development of a new CVS APP practice model. The goal was to develop …

A Study Of Onboarding And Turnover Mediating Variables In U.S. Air Force Officers, Brett S. Bowers

Theses and Dissertations

Employee retention, while always a concern in the workplace, has become a greater challenge for organizations in recent years. Today’s working class has displayed a propensity to change jobs more rapidly than previous generations, exacerbating not only turnover rates but also the costs associated with them (Frankel, 2016). This challenge is especially relevant to the United States Air Force, which has experienced difficulty retaining young officers in recent years. The problems resulting from this voluntary turnover are exceedingly impactful to the military command structure, as senior leaders must work their way up from the lowest ranks. As such, the Air …

Optimization Of The Retention Rates Of Ready Mix Usa Drivers, Pruthvi Hira, Jaime Harmon, Kenneth Correa, Destiny Sessums

Senior Design Project For Engineers

Ready Mix USA, a CEMEX company, is a giant in the building materials industry, servicing the Southeastern region of the United States through various commercial and residential projects. The Atlanta Division of RMUSA currently consists of 15 operational plants in the state of Georgia with its headquarters located in Woodstock. From the years 2015 to 2018, managers at Ready Mix USA noticed a drastic increase in turnover rates of ready mix truck drivers and did not have an answer for the increasing percentages. The Continuous Improvement at RMUSA tasked the student project team from the Industrial and Systems Engineering department …

Class-Based Storage With A Finite Number Of Items, Yugang Yu, René B.M. De Koster

11th IMHRC Proceedings (Milwaukee, Wisconsin. USA – 2010)

ABC class-based storage is widely studied in literature and applied practice. It divides all stored items into a limited number of classes according to their demand rates (turnover per unit time). Classes of items with higher turnovers are stored in a region closer to the warehouse depot. In literature, it is commonly shown that the use of more storage classes leads to shorter travel time for storing and retrieving items. A basic assumption in this literature commonly is that the required storage space of items equals their average inventory levels, which is right if an infinite number of items are …