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Magnetic Softness Tuned Superparamagnetic Nanoparticles For Highly Efficient Cancer Theranostics, Jie Wang
Magnetic Softness Tuned Superparamagnetic Nanoparticles For Highly Efficient Cancer Theranostics, Jie Wang
Theses and Dissertations
Magnetic resonance imaging (MRI)-guided magnetic nanofluid hyperthermia (MNFH) using iron oxide based superparamagnetic nanoparticles (SPNPs) has recently attracted considerable attention as a treatment modality for cancer theranostics, because MRI-guided MNFH can allow for diagnosis, therapeutics, and prognosis simultaneously using the same administrated magnetic nanofluid agent. However, several primary limiting factors: (1) insufficient AC magnetic heating induction (specific loss power/intrinsic loss power, SLP/ILP) at the biologically safe and physically tolerable range of AC magnetic field (HAC,safe: fappl × Happl < 3.0 ~ 5.0×109 A·m-1·s-1), (2) low r2- relaxivity directly related to the low resolution of …