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Full-Text Articles in Engineering
Magnetic Softness Tuned Superparamagnetic Nanoparticles For Highly Efficient Cancer Theranostics, Jie Wang
Magnetic Softness Tuned Superparamagnetic Nanoparticles For Highly Efficient Cancer Theranostics, Jie Wang
Theses and Dissertations
Magnetic resonance imaging (MRI)-guided magnetic nanofluid hyperthermia (MNFH) using iron oxide based superparamagnetic nanoparticles (SPNPs) has recently attracted considerable attention as a treatment modality for cancer theranostics, because MRI-guided MNFH can allow for diagnosis, therapeutics, and prognosis simultaneously using the same administrated magnetic nanofluid agent. However, several primary limiting factors: (1) insufficient AC magnetic heating induction (specific loss power/intrinsic loss power, SLP/ILP) at the biologically safe and physically tolerable range of AC magnetic field (HAC,safe: fappl × Happl < 3.0 ~ 5.0×109 A·m-1·s-1), (2) low r2- relaxivity directly related to the low resolution of …
Nanoparticles For Targeted Drug Delivery To Cancer Stem Cells: A Review Of Recent Advances, Yavuz Nuri Ertas, Keyvan Abedu Dorcheh, Ali Akbari, Esmaiel Jabbari
Nanoparticles For Targeted Drug Delivery To Cancer Stem Cells: A Review Of Recent Advances, Yavuz Nuri Ertas, Keyvan Abedu Dorcheh, Ali Akbari, Esmaiel Jabbari
Faculty Publications
Cancer stem cells (CSCs) are a subpopulation of cells that can initiate, self-renew, and sustain tumor growth. CSCs are responsible for tumor metastasis, recurrence, and drug resistance in cancer therapy. CSCs reside within a niche maintained by multiple unique factors in the microenvironment. These factors include hypoxia, excessive levels of angiogenesis, a change of mitochondrial activity from aerobic aspiration to aerobic glycolysis, an upregulated expression of CSC biomarkers and stem cell signaling, and an elevated synthesis of the cytochromes P450 family of enzymes responsible for drug clearance. Antibodies and ligands targeting the unique factors that maintain the niche are utilized …
Time-Domain Measurement Of Magnetization Dynamics In Ferrofluids, Brian Egenriether
Time-Domain Measurement Of Magnetization Dynamics In Ferrofluids, Brian Egenriether
Theses and Dissertations
Time-domain measurements are made on a magnetite-based (Fe3O4) ferrofluid using an inductive technique. The constituent particles are 5.8% by volume, polydisperse, and have a nominal diameter of 10nm with a ~1nm-thick anionic hydrophobic coating. The ferrofluid is placed in a sealed channel on a coplanar waveguide (CPW) situated in an adjustable external magnetic bias field. A fast-rising step current in the CPW quickly reorients the local magnetic field above the signal trace causing the particles’ moments to align in the new field configuration. This changing magnetization induces a voltage in the CPW that is detected by a sampling oscilloscope. Precessional …