Engineering Commons^™

Quickcough: An Instrumentational Proximal Airway Clearance Technique (Act) For Select Patients With Neuromuscular Disease (Nmd), Sean X. Sullivan, Russell K. Catania, Madison K. Plaster, Sydney E. Kandray, Mariah Costa

Williams Honors College, Honors Research Projects

Patients with neuromuscular disease (NMD) requiring tracheostomy and mechanical ventilation secondary to respiratory failure encounter increased difficulty in removing pulmonary secretions from the airways. To combat issues associated with current treatment modalities for insufficient cough efficacy (cost, poor mobility, discomfort, lack of evidence), we have developed an instrumentational proximal airway clearance technique (ACT) which augments a manual proximal ACT developed by a client with NMD. QuickCough is a 3D-printed PLA attachment to the tracheostomy apparatus which has demonstrated its ability to facilitate pressure changes necessary to increase patient’s peak cough flow (PCF) by providing a stronger exsufflation for the patient. …

Purdue’S Biowall, Purdue Ect Team

ECT Fact Sheets

Mechanical ventilation, energy recovery ventilation, and infiltration (air that leaks into a building) are commonly used to introduce fresh air. These are all valid approaches, but a living plant-based filter is an innovative complement to these traditional technologies. A Biowall has the potential to improve indoor air quality while reducing the quantity of air needed for ventilation, creating the potential for energy savings. Figure 1 shows a Biowall prototype being evaluated in the ReNEWW House, a research home located near the Purdue University campus (http://www.renewwhouse.com/).

Measurement Of The Frequency Response Of Clinical Gas Analysers, Kabita Shakya, Catherine Deegan, Fran Hegarty, Charles Markham

The ITB Journal

A technique for the time and frequency response measurement of clinical CO2 analysers has been established. The time and frequency response of several analyser systems has been determined. This paper presents the case for the routine measurement of the dynamic performance of such systems in the context of their application in high-frequency ventilation schemes. The importance of these measurements has been demonstrated in the comparison of older and newer systems in the sense that older systems demonstrate significant deterioration in peiformance. In the context of the use of capnographs in life-support systems, it is essential to measure and monitor the …

Determination Of The Frequency Response Of An End Tidal Co2 Analyser, Kabita Shakya, Catherine Deegan, Fran Hegarty

The ITB Journal

In a health care environment, mechanical ventilation is used to support patients during acute illness and surgery. Mechanical ventilation is the process by which the patient’s respiratory function is artificially supported using a respirator. During mechanical ventilation, it is necessary to ensure the adequacy of ventilation. The patient is thus monitored for several ventilatory parameters. The end-tidal CO2 (EtCO2) is one of the primary monitoring parameters. EtCO2 is the partial pressure or maximal concentration of carbon dioxide (CO2) at the end of an exhaled breath, which is expressed as a percentage of CO2 or mmHg . Capnography is the technique …

Multiscale Modeling Of Airway Inflammation Induced By Mechanical Ventilation, Kittisak Koombua

Theses and Dissertations

Mechanical ventilation (MV) is a system that partially or fully assists patients whose respiratory system fails to achieve a gas exchange function. However, MV can cause a ventilator-associated lung injury (VALI) or even contribute to a multiple organ dysfunction syndrome (MODS) in acute respiratory distress syndrome (ARDS) patients. Despite advances in today technologies, mortality rates for ARDS patient are still high. A better understanding of the interactions between airflow from mechanical ventilator and the airway could provide useful information used to develop a better strategy to ventilate patients. The mechanisms, which mechanical ventilation induces airway inflammation, are complex processes and …

Airway Strain During Mechanical Ventilation In An Intact Animal Model, Scott W. Sinclair, Robert C. Molthen, Steven Thomas Haworth, Christopher A. Dawson, Christopher M. Waters

Biomedical Engineering Faculty Research and Publications

Rationale: Mechanical ventilation with large tidal volumes causes ventilator-induced lung injury in animal models. Little direct evidence exists regarding the deformation of airways in vivo during mechanical ventilation, or in the presence of positive end-expiratory pressure (PEEP).

Objectives: To measure airway strain and to estimate airway wall tension during mechanical ventilation in an intact animal model.

Methods: Sprague-Dawley rats were anesthetized and mechanically ventilated with tidal volumes of 6, 12, and 25 cm³/kg with and without 10–cm H₂O PEEP. Real-time tantalum bronchograms were obtained for each condition, using microfocal X-ray imaging. Images were …