Engineering Commons^™

Covalently Crosslinked Organic/Inorganic Hybrid Biomaterials For Bone Tissue Engineering Applications, Dibakar Mondal

Electronic Thesis and Dissertation Repository

Scaffolds are key components for bone tissue engineering and regeneration. They guide new bone formation by mimicking bone extracellular matrix for cell recruitment and proliferation. Ideally, scaffolds for bone tissue engineering need to be osteoconductive, osteoinductive, porous, degradable and mechanically competent. As a single material can not provide all these requirements, composites of several biomaterials are viable solutions to combine various properties. However, conventional composites fail to fulfil these requirements due to their distinct phases at the microscopic level. Organic/inorganic (O/I) class II hybrid biomaterials, where the organic and inorganic phases are chemically crosslinked on a molecular scale, hence the …

Synthesis, Characterization And Applications Of Lignin-Based Epoxy Resins, Fatemeh Ferdosian

Electronic Thesis and Dissertation Repository

Epoxy resin is one of the most versatile thermosetting polymers with diverse applications. Epoxy resins are mainly produced from the reaction of bisphenol-A (BPA) and epichlorohydrin. The consumption of bisphenol-A is facing growing concerns over its carcinogenic effects and its sustainability. Lignin can be a promising renewable substitute of bisphenol-A in the synthesis of epoxy resins.

In this thesis work, a novel method has been developed for the synthesis of bio-based epoxy resins with reduced side reactions, employing de-polymerized lignin from organosolv lignin (DOL), kraft lignin (DKL) and hydrolysis lignin (DHL) under alkaline condition in the presence of a phase …

Sol-Gel Derived Biodegradable And Bioactive Organic-Inorganic Hybrid Biomaterials For Bone Tissue Engineering, Bedilu A. Allo

Electronic Thesis and Dissertation Repository

Treatments of bone injuries and defects have been largely centered on replacing the lost bone with tissues of allogeneic or xenogeneic sources as well as synthetic bone substitutes, which in all lead to limited degree of structural and functional recovery. As a result, tissue engineering has emerged as a viable technology to regenerate the structures and therefore recover the functions of bone tissue rather than replacement alone. Hence, the current strategies of bone tissue engineering and regeneration rely on bioactive scaffolds to mimic the natural extracellular matrix (ECM) as templates onto which cells attach, multiply, migrate and function.

In this …