Engineering Commons^™

Developmental And Sex Modulated Neurological Alterations In Autism Spectrum Disorder, Azeezat Azeez

Dissertations

Autism Spectrum Disorder (ASD) was first described in 1943 by Dr. Leo Kranner in a case study published in The Nervous Child. It is a neurodevelopment disorder, with a range of clinical symptoms. According to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), used by clinicians to diagnose mental disorders, a child needs to have persistent social deficits, language impairments, and repetitive behaviors, that cannot be explained by neurological damage or intellectual disability. It is known that children diagnosed with ASD are often are developmentally delayed therefore alterations in the typical developmental trajectory should be a major factor in …

Quantitatively Studying Tissue Damage In Multiple Sclerosis Using Gradient Recalled Echo Mri Sequences, Biao Xiang

Arts & Sciences Electronic Theses and Dissertations

Multiple Sclerosis (MS) is an unpredictable, often disabling disease of the central nervous system (CNS) that disrupts the flow of information within the brain, and between the brain the body. MS is the most common progressive neurologic disease of young adults, affecting approximately 2.3 million people worldwide. It is estimated that more than 700,000 individuals are affected by MS in United States. While MS has been studied for decades, the cause of it is still not definite and a fully effective treatment for MS is not yet available. Magnetic resonance imaging (MRI) has been used extensively in MS diagnosis and …

Quantitatively Studying Tissue Damage In Multiple Sclerosis Using Gradient Recalled Echo Mri Sequences, Biao Xiang

Arts & Sciences Electronic Theses and Dissertations

Multiple Sclerosis (MS) is an unpredictable, often disabling disease of the central nervous system (CNS) that disrupts the flow of information within the brain, and between the brain the body. MS is the most common progressive neurologic disease of young adults, affecting approximately 2.3 million people worldwide. It is estimated that more than 700,000 individuals are affected by MS in United States. While MS has been studied for decades, the cause of it is still not definite and a fully effective treatment for MS is not yet available.

Magnetic resonance imaging (MRI) has been used extensively in MS diagnosis and …

Muscle Activation Via Mri: Comparison Of Techniques, Logan Thorneloe, Neal Bangerter

Journal of Undergraduate Research

Muscle functional magnetic resonance imaging (mfMRI) is a proven concept to non-invasively identify muscle activation1. Noninvasively identifying muscle activation can be used to diagnose metabolic muscle disease, identify and pinpoint muscular dysfunction, observe muscle deterioration in aging individuals, and help researchers better understand the biological foundation of musclechemistry2. Current proven methods of mfMRI include analyzing pre- and post-exercise T2-weighted images, T2 maps, and sodium images of muscle; however, there is considerable debate around the best of these techniques1-4. We tested these three imaging techniques to determine which has the greatest post-exercise shift in signal intensity.

Novel Calibrated Short Tr Recovery (Castrr) Method For Brain-Blood Partition Coefficient Correction Enhances Gray-White Matter Contrast In Blood Flow Measurements In Mice, Scott W. Thalman, David K. Powell, Ai-Ling Lin

Biomedical Engineering Faculty Publications

The goal of the study was to develop a novel, rapid Calibrated Short TR Recovery (CaSTRR) method to measure the brain-blood partition coefficient (BBPC) in mice. The BBPC is necessary for quantifying cerebral blood flow (CBF) using tracer-based techniques like arterial spin labeling (ASL), but previous techniques required prohibitively long acquisition times so a constant BBPC equal to 0.9 mL/g is typically used regardless of studied species, condition, or disease. An accelerated method of BBPC correction could improve regional specificity in CBF maps particularly in white matter. Male C57Bl/6N mice (n = 8) were scanned at 7T using CaSTRR …

Decoupling Network For Tx/Rx Body Coil For 7t Mri, Ashraf Abuelhaija, Sana Salamh, Osama Nashwan

Turkish Journal of Electrical Engineering and Computer Sciences

The parallel imaging technique is widely used in 7T MRI scanners. It employs multichannel RF coil arrays to apply a concurrent excitation and acquisition method. Concurrent excitation faces significant challenges in terms of electromagnetic coupling between the RF coil elements. In order to prevent interference between the RF coil elements' exciters, several decoupling methods have been developed to compensate for coupling and to permit independent work for the exciters. This paper studies the coupling between meander coils arranged in two different geometrical setups and investigates the isolation performance between the coils by applying two different decoupling networks depending on the …

Iterative Sensitivity Matrix-Based Magnetic Resonance Conductivity Tensor Imaging, Evren Deği̇rmenci̇

Turkish Journal of Electrical Engineering and Computer Sciences

Magnetic resonance conductivity tensor imaging (MRCTI) reconstructs high-resolution anisotropic conductivity images, which are proved to have critical importance in radio-oncological imaging as well as source localization fields. In the MRCTI technique, linearly independent current injections are applied to the region to be imaged and resulting magnetic flux densities are measured using magnetic resonance imaging techniques. In this study, a novel iterative reconstruction algorithm based on a sensitivity matrix approach is proposed and tested using both simulated and experimental measurements. Obtained results show that the proposed technique can reconstruct anisotropic conductivity images with high and position-independent spatial resolution in addition to …