Engineering Commons^™

Tau Kinetics In Alzheimer's Disease, Daniel B. Hier, Sima Azizi, Matthew S. Thimgan, Donald C. Wunsch

Chemistry Faculty Research & Creative Works

The Cytoskeletal Protein Tau is Implicated in the Pathogenesis of Alzheimer's Disease Which is Characterized by Intra-Neuronal Neurofibrillary Tangles Containing Abnormally Phosphorylated Insoluble Tau. Levels of Soluble Tau Are Elevated in the Brain, the CSF, and the Plasma of Patients with Alzheimer's Disease. to Better Understand the Causes of These Elevated Levels of Tau, We Propose a Three-Compartment Kinetic Model (Brain, CSF, and Plasma). the Model Assumes that the Synthesis of Tau Follows Zero-Order Kinetics (Uncorrelated with Compartmental Tau Levels) and that the Release, Absorption, and Clearance of Tau is Governed by First-Order Kinetics (Linearly Related to Compartmental Tau Levels). …

Surface Flashover Under Various Surface Conditions, Bradley A. Hannum

Electrical Engineering Theses

Electrical insulators are critical components used in every high voltage application whether it is operated continuously or in a pulsed mode. Bulk dielectric breakdown and surface flashover must be prevented in all use cases, especially those that occur in polluted environments. Though electrical standards have been written as a guide to prevent insulator surface flashover, such as Underwriters Laboratories (UL) 840, they are not directly applicable to applications where size and weight are critical. UL 840 experimental design is vague, does not consider all environments, and is written primarily with the electric power utilities in mind. The research presented here …

Method Of Determining The Parameters Of The Working Bodies Of The Centrifugal Fan Installed To The Sprayer, D. Dzhuraev, M.S. Halilov, I.Zh. Toirov, A.E. Urishev

Irrigation and Melioration

The article presents the data of scientists who conducted theoretical and experimental research on centrifugal fans, they refined the calculations, improved technical characteristics and aerodynamic designs of centrifugal fans. Aerodynamic and technological schemes of centrifugal fans installed to the sprayer have been developed. The theoretical and experimental studies conducted by scientists are described: Nevelson MI, Cherkassky VM, Kalinushkin MP, Ivanov O. P., Turbin B. G., on the basis of which the authors developed a method for calculating the main parameters of the working bodies centrifugal fan. Based on the developed calculation methodology, the main parameters of the working bodies of …

Implementation And Characterization Of Solvent Detergent Viral Inactivation In Single Use Bags, Michael Cunningham, Ven Raman, Nitin Sood, Jessica Shea, Lori Mullin, Eric Youssef, Pedro Almeida, Elizabeth Goodrich

Single-Use Technologies: Bridging Polymer Science to Biotechnology Applications

Biomanufacturing of recombinant products from mammalian cell culture systems and plasma derived products requires at least two orthogonal virus reduction steps to comply with regulatory pathogen safety risk mitigation guidelines. Solvent detergent viral inactivation (SD VI) has historically been effectively utilized for the inactivation of lipid-enveloped viruses from plasma derived products, yet only recently have process development activities focused on implementation of SD VI in single use systems. The adoption of single-use technologies for bioproduction continues to progress, driven predominantly by the benefits of operational flexibility, speed of implementation, lower capital investment, and elimination of cross contamination concerns. However, the …

The Practical Application Of Bpog E&L Protocols To Viral Clearance Filters, Paul Killian, Thomas Stone, Jessica Shea

Single-Use Technologies: Bridging Polymer Science to Biotechnology Applications

Regulatory guidance advocates virus control at various stages of the drug manufacturing process and directs that you test the capacity of the process to remove or inactivate virus. Patient safety concerns require you to determine what impurities may be added by the virus control steps you implement. While the application of a standardized approach to identifying and quantifying the extractables from these steps has benefits when making comparisons, choices have to be made when developing the protocol that take into account the characteristics of the clearance device and use conditions This presentation will illustrate the practical implementation of standardized extractables …

Headache Be Gone: Clearance Of Extractables And Leachables In Single-Use Technologies Through Ultrafiltration/Diafiltration, Kate Lee, Nicholas Magarian, Kunal Nagpal, Ekta Mahajan, Kenneth Skidmore

Single-Use Technologies: Bridging Polymer Science to Biotechnology Applications

Application of single-use technologies in biopharmaceutical manufacturing can be driven by several factors such as reduced capital costs, reduced risk of cross-contamination, increased process flexibility, and reduced cleaning validation. However, implementation of single-use technologies have been restricted due to a number of concerns, with the most commonly cited being the presence of extractables and leachables (E/L) from single-use technologies. In general, overly conservative estimates of E/L are used in the risk assessment due to lack of data on clearance, resulting in a time-consuming, costly, and extensive E/L assessment for single-use technologies.

A proof-of-concept study is presented here to simplify these …

Examination Of Factors Affecting The Frequency, Response Time, And Clearance Time Of Incidents On Freeways, Indrajit Ghosh

Wayne State University Dissertations

Traffic incidents are the primary cause of non-recurrent congestion in urban areas, resulting in reductions in roadway capacity and significant safety hazards to other motorists, as well as first responders. Many communities have initiated incident management programs that detect and respond to incidents and restore freeways to full capacity by clearing the incident scene as soon as possible. In the Detroit metro area, the Michigan Department of Transportation (MDOT) operates a Freeway Courtesy Patrol (FCP) program as part of its larger freeway incident management program from the Michigan Intelligent Transportation Systems (MITS) Center in downtown Detroit. The MITS Center maintains …

Development Of Kentucky’S Highway Incident Management Strategic Plan, Monica L. Barrett, Joseph D. Crabtree, Jerry G. Pigman, Jennifer R. Walton

Kentucky Transportation Center Research Report

Even though Kentucky has undertaken many initiatives to improve specific aspects of incident management, there has never been a plan that establishes an overall framework for a systematic, statewide, multi-agency effort to improve the management of highway incidents. The objective of this project was to develop a strategic plan that provides a vision and strategy for significantly improving all aspects of incident management. This report identifies the current and best practices for highway incident management in the United States and in Kentucky and establishes a vision for the future of highway incident management in Kentucky. The Plan developed through the …

Crash Rates At Intersections, Eric R. Green, Kenneth R. Agent

Kentucky Transportation Center Research Report

The objectives of this study were to develop a database of intersections, match traffic crashes to these intersections, calculate crash rates for various types of intersections, and identify intersections with the highest crash rates. A procedure was used to: a) identify intersections, b) assign crashes to these intersections, c) determine entering traffic volume, d) calculate a crash rate for each intersection, and e) calculate a critical rate factor (CRF) for each intersection.

About 7,000 intersections were identified with almost 19,000 crashes related to these intersections for the three-year period of 2000 through 2002. The analysis identified 428 intersections that had …

Highway Crash Site Management, Monica L. Barrett, Jennifer R. Walton

Kentucky Transportation Center Research Report

Traveler delay is the problem most often associated with highway crashes, but by far the most serious problem is the resulting secondary crashes that occur. Another related issue is the danger posed to response personnel serving the public at the scene of a crash. The longer a crash is in place, the longer the responders are vulnerable and exposed to injury.

The Kentucky Transportation Center, in cooperation with the Kentucky Transportation Cabinet, developed a checklist and interagency workshop to address ways to secure and coordinate the resources necessary to restore the roadway’s operation in a safe and timely manner. The …