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Single-Pixel Camera Based Spatial Frequency Domain Imaging For Non-Contact Tissue Characterization, Alec M. Petrack

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Optical imaging has demonstrated potential as a medical imaging modality for measuring tissue functionality. Recently, interest in fluorescence guided surgery has emerged from improvements in optical imaging that have allowed real-time feedback. Of the optical imaging modalities, spatial frequency domain imaging (SFDI) has gained a lot of interest. Unlike spectroscopic techniques, such as functional near infrared spectroscopy (fNIRS) and frequency domain spectroscopy that measure bulk tissue properties, SFDI quantifies tissue functionality locally and wide field making it practical for clinical applications. Unfortunately, traditional SFDI systems use multi-pixel detectors, which may not exhibit ideal spectral characteristics, have limited sensitivity, be expensive, …