Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Biomedical Engineering (5)
- Department of Biomedical, Industrial & Human Factors Engineering (5)
- Biomedical Sciences (3)
- Neurosciences (3)
- Biomedical Research (2)
-
- Cellular Biology (2)
- EEG (2)
- ALS (1)
- Acid sphingomyelinase (1)
- Alpha (1)
- Alpha-synuclein (1)
- Attention (1)
- Biology (1)
- Brain-computer interface (1)
- Cell polarity (1)
- Cell-system anti-cancer therapy (1)
- Cognitive probing (1)
- Compressed sensing (1)
- Compressed single pixel imaging (1)
- EGFR (1)
- Genetic interactions (1)
- Genetics (1)
- Hip replacements (1)
- Human modifier genes (1)
- Immunosuppression (1)
- Kv2 channels (1)
- MEF2 (1)
- Mechanism of action (1)
- Microvesicle particle (1)
- Motor neuron (1)
Articles 1 - 8 of 8
Full-Text Articles in Engineering
Single-Pixel Camera Based Spatial Frequency Domain Imaging For Non-Contact Tissue Characterization, Alec M. Petrack
Single-Pixel Camera Based Spatial Frequency Domain Imaging For Non-Contact Tissue Characterization, Alec M. Petrack
Browse all Theses and Dissertations
Optical imaging has demonstrated potential as a medical imaging modality for measuring tissue functionality. Recently, interest in fluorescence guided surgery has emerged from improvements in optical imaging that have allowed real-time feedback. Of the optical imaging modalities, spatial frequency domain imaging (SFDI) has gained a lot of interest. Unlike spectroscopic techniques, such as functional near infrared spectroscopy (fNIRS) and frequency domain spectroscopy that measure bulk tissue properties, SFDI quantifies tissue functionality locally and wide field making it practical for clinical applications. Unfortunately, traditional SFDI systems use multi-pixel detectors, which may not exhibit ideal spectral characteristics, have limited sensitivity, be expensive, …
Global Joint Registry: Analysis Of Revision Hip Arthroplasty Data, Alicia M. Runser
Global Joint Registry: Analysis Of Revision Hip Arthroplasty Data, Alicia M. Runser
Browse all Theses and Dissertations
Total hip arthroplasty (THA) has become well-known as being one of the most successful procedures with much long-term positive clinical results. However, revision surgeries are still required. The four most common failure modes for THAs, “reasons for revision”, are loosening, dislocation or instability, fracture, and infection. The goal of a hip arthroplasty register is to gather information on patients that undergo a total hip arthroplasty and factors pertaining to their surgery which may affect their outcome for future years such as the reason for revision. Analysis of this data can help with the allocation of healthcare funds and the efficacy …
Observing P300 Amplitudes In Multiple Sensory Channels Using Cognitive Probing, Cody Lee Wintermute
Observing P300 Amplitudes In Multiple Sensory Channels Using Cognitive Probing, Cody Lee Wintermute
Browse all Theses and Dissertations
High cognitive workload occurs when excessive working memory resources have been deployed to resolve sensory and cognitive processing, resulting in decremented task performance. The P300 event-related potential (ERP) component has shown sensitivity to cognitive load, and it was hypothesized that an attenuated P300 amplitude could be indicative of high cognitive load. We tested this hypothesis by having eight participants complete two continual performance tasks at increasing workload levels while simultaneously performing an oddball task, evoking P300 ERPs in either the auditory or tactile sensory channel. In our experiment, electroencephalographic recordings were collected over the parietal region to observe the P300 …
Kv2.1 Channel Clustering In The Sod1-G93a Mouse Model Of Als, Joshua Christopher Harris
Kv2.1 Channel Clustering In The Sod1-G93a Mouse Model Of Als, Joshua Christopher Harris
Browse all Theses and Dissertations
Kv2.1 channels mediate slow-activating K+ rectifier current within the membrane of spinal motoneurons (MNs), and they are known to co-localize with other synapses and ion channels. Although Kv2.1 channels are suggested to regulate MN excitability, little research has gone into investigating its potential contribution to MN-altered excitability in Amyotrophic Lateral Sclerosis (ALS). Using the male SOD1-G93A mouse model of ALS, we examined Kv2.1 cluster area and density in lumbar MNs at four key stages of disease progression. In our experiments, MNs were separated by type via SK3 immunoreactivity in order to isolate and compare the responses of disease-resistant (slow; SK3+) …
Renca Macrobeads Inhibit Tumor Cell Growth Via Egfr Activation And Regulation Of Mef2 Isoform Expression, Prithy Caroline Martis
Renca Macrobeads Inhibit Tumor Cell Growth Via Egfr Activation And Regulation Of Mef2 Isoform Expression, Prithy Caroline Martis
Browse all Theses and Dissertations
Tumors are heterogeneous systems, whose growth is influenced by intrinsic properties of malignant cells, external systemic factors (i.e. immune, neural, endocrine, etc.), and the dynamic interactions between tumor cells and their microenvironment. Given the inherent complexity of cancers, combined with the continual evolution of tumors and the development of treatment resistance, a precision medicine approach may not provide an optimal clinical response. Exploring a new paradigm that focuses on regulating cancer as a system may not only control tumor progression but also address the extraordinary challenges of tumor heterogeneity and disease recurrence in order to improve clinical outcomes. As a …
Global Identification Of Human Modifier Genes Of Alpha-Synuclein Toxicity, Ishita Haider
Global Identification Of Human Modifier Genes Of Alpha-Synuclein Toxicity, Ishita Haider
Browse all Theses and Dissertations
Alpha-synuclein is a small lipid binding protein abundantly expressed in the brain. Lewy body or Lewy-like pathology, primarily composed of misfolded alpha-synuclein, is a pathological feature shared by several neurodegenerative disorders, including Parkinson's disease (PD). Both missense mutations and increased copy numbers of the SNCA gene, encoding the alpha-synuclein protein, have been genetically linked to autosome dominant PD. Other genetic variations affecting the expression of the SNCA gene have been associated with sporadic PD. Although the physiological function of alpha-synuclein is not well understood, its localization to plasma and vesicular membranes at the presynaptic terminals suggests a role in neurotransmission. …
Visual Sampling With The Eeg Alpha Oscillation, Kevin Eugene Alexander
Visual Sampling With The Eeg Alpha Oscillation, Kevin Eugene Alexander
Browse all Theses and Dissertations
The posterior alpha rhythm, seen in human electroencephalograms (EEG), is posited to originate from cycling inhibitory/excitatory states of visual relay cells in the thalamus, which could result in discrete sampling of visual information. Here, we tested this hypothesis by presenting light flashes at perceptual threshold intensity through closed eyelids to 20 participants during times of spontaneous alpha oscillations. Alpha phase and amplitude were calculated relative to each individual’s retina-to-V1 conduction delay, estimated by the individuals’ C1 visual-evoked potential latency. Our results show that an additional 20.96% of stimuli are observed when afferenting at V1 during an alpha wave trough (272.41°) …
Ultraviolet-B Radiation Induces Release Of Bioactive Microvesicle Particles In Keratinocytes Via Platelet-Activating Factor And Acid Sphingomyelinase, Langni Liu
Browse all Theses and Dissertations
Ultraviolet-B (UV-B) radiation is one of the most common environmental factors and is known to induce the production of bioactive agents that cause several diseases including skin cancer. UVB exposure stimulates the production of a phospholipid activator, platelet-activating factor (PAF), and its analogs in keratinocytes that activate the PAF receptor (PAF-R) resulting in acute inflammatory and delayed systematic immunosuppressive effects. However, as UVB only penetrates into the skin epidermal layer, the detailed mechanisms of how UVB exerts systematic effects remains unclear. Previously we found that UVB induces keratinocytes to release large numbers of microvesicle particles (MVPs). These small membrane-bound particles …