Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Engineering
An Elastic-Net Logistic Regression Approach To Generate Classifiers And Gene Signatures For Types Of Immune Cells And T Helper Cell Subsets, Arezo Torang, Paraag Gupta, David J. Klinke Ii
An Elastic-Net Logistic Regression Approach To Generate Classifiers And Gene Signatures For Types Of Immune Cells And T Helper Cell Subsets, Arezo Torang, Paraag Gupta, David J. Klinke Ii
Faculty & Staff Scholarship
Background: Host immune response is coordinated by a variety of different specialized cell types that vary in time and location. While host immune response can be studied using conventional low-dimensional approaches, advances in transcriptomics analysis may provide a less biased view. Yet, leveraging transcriptomics data to identify immune cell subtypes presents challenges for extracting informative gene signatures hidden within a high dimensional transcriptomics space characterized by low sample numbers with noisy and missing values. To address these challenges, we explore using machine learning methods to select gene subsets and estimate gene coefficients simultaneously. Results: Elastic-net logistic regression, a type of …
Application Of Machine Learning And Artificial Intelligence In Proxy Modeling For Fluid Flow In Porous Media, Shohreh Amini, Shahab Mohaghegh
Application Of Machine Learning And Artificial Intelligence In Proxy Modeling For Fluid Flow In Porous Media, Shohreh Amini, Shahab Mohaghegh
Faculty & Staff Scholarship
Reservoir simulation models are the major tools for studying fluid flow behavior in hydrocarbon reservoirs. These models are constructed based on geological models, which are developed by integrating data from geology, geophysics, and petro-physics. As the complexity of a reservoir simulation model increases, so does the computation time. Therefore, to perform any comprehensive study which involves thousands of simulation runs, a very long period of time is required. Several efforts have been made to develop proxy models that can be used as a substitute for complex reservoir simulation models. These proxy models aim at generating the outputs of the numerical …