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Articles 1 - 4 of 4
Full-Text Articles in Engineering
Offset Electrodes For Enhanced Neural Recording In Microchannels, Iian Black
Offset Electrodes For Enhanced Neural Recording In Microchannels, Iian Black
FIU Electronic Theses and Dissertations
Microchannel electrodes have emerged in recent years as promising interfaces for recording signals in peripheral nerves. Unlike many technologies, microchannels maintain stable long-term connections and can record activity in individual or small groups of axons. Unfortunately, a traditional symmetrical mid-channel electrode configuration, designed to reduce noise artifacts, prevents microchannels from being used to distinguish between signals traveling in opposite directions. This is a profound limitation given that most nerves contain a mix of efferent and afferent axons and microchannels were initially conceived and later used as the basic building block in arrays designed to record bi-directional neural traffic in regenerated …
Synergistic Activation Of Inspiratory Muscles By An Adaptive Closed-Loop Controller, Rabeya Zinnat Adury
Synergistic Activation Of Inspiratory Muscles By An Adaptive Closed-Loop Controller, Rabeya Zinnat Adury
FIU Electronic Theses and Dissertations
During diaphragmatic pacing reverse recruitment of muscle fibers causes muscle fatigue. Current diaphragmatic pacing paradigms also do not permit sigh-like behavior. In spontaneously breathing anesthetized rats, studies were carried out to determine if synergized pacing of external intercostal muscles and the diaphragm would increase the efficiency of diaphragm stimulation and thus a) achieve the desired ventilatory breath volume profile with reduced diaphragm muscle fatigue, and/or b) be able to elicit sigh-like behavior by periodically increasing stimulation. Under combined inspiratory muscle stimulation, a fatigue index calculated for the diaphragm muscle (n=6 rats) was significantly lower (p<0.05) than in the …
Adaptive Closed-Loop Neuromorphic Controller For Use In Respiratory Pacing, Ricardo Siu
Adaptive Closed-Loop Neuromorphic Controller For Use In Respiratory Pacing, Ricardo Siu
FIU Electronic Theses and Dissertations
Respiratory pacing can treat ventilatory insufficiency through electrical stimulation of the respiratory muscles, or the respective innervating nerves, to induce ventilation. It avoids some of the adverse effects associated with mechanical ventilation such as risk of diaphragm atrophy and lung damage. However, current respiratory pacing systems provide stimulation in an open-loop manner. This often requires users to undergo frequent tuning sessions with trained clinicians if the specified stimulation parameters are unable to induce sufficient ventilation in the presence of time-varying changes in muscle properties, chest biomechanics, and metabolic demand. Lack of adaptation to these changes may lead to complications arising …
Multiscale Model Of Cerebral Blood Flow Control: Application To Small Vessel Disease And Cortical Spreading Depression, Arash Moshkforoush
Multiscale Model Of Cerebral Blood Flow Control: Application To Small Vessel Disease And Cortical Spreading Depression, Arash Moshkforoush
FIU Electronic Theses and Dissertations
An in-time delivery of oxygen-rich blood into areas of high metabolic demand is pivotal in proper functioning of the brain and neuronal health. This highly precise communication between neuronal activity and cerebral blood flow (CBF) is termed as neurovascular coupling (NVC) or functional hyperemia. NVC is disrupted in major pathological conditions including Alzheimer’s disease, dementia, small vessel pathologies (SVD) and cortical spreading depression. Despite the utmost importance of NVC, its underlying mechanisms are not fully understood. This dissertation presents a multiscale mathematical modeling framework for studying unresolved mechanisms of NVC with major focus on K+ ions as a mediator …