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Thermodynamically-Constrained Computational Modeling Of Lung Tissue Bioenergetics And The Effect Of Hyperoxia-Induced Acute Lung Injury, Xiao Zhang
Dissertations (1934 -)
Altered lung tissue bioenergetics is an important and early step in the pathogenesis of acute lung injury (ALI), one of the most common causes of admission to medical ICUs. A wealth of information exists regarding the effect of ALI on specific mitochondrial and cytosolic processes in isolated mitochondria, cultured endothelial cell, and intact lungs. However, the interdependence of lung cellular processes makes it difficult to quantify the impact of a change in a single or multiple cellular process(es) on overall lung tissue bioenergetics. Integrating bioenergetics data from isolated mitochondria and intact lung is necessary for determining the functional significance of …