Engineering Commons^™

Effect Of Physical Stimuli On Angiogenic Factor Expression In Retinal Pigment Epithelial Cells, Farhad Farjood

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Age-related macular degeneration (AMD) is a major cause of blindness in adults. Abnormal growth of blood vessels in the eye during the course of AMD causes damage to the retina, resulting in irreversible blindness. The goal of this research was to determine whether physical pressure on retinal cells can contribute to the increased blood vessel formation. To replicate the tears in the cell layers, a micropatterning method was used as a means of detaching cells from each other. Two new devices were also developed to mimic slow and fast increases in mechanical pressure on cell layers of the eye. After …