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Full-Text Articles in Engineering
Novel Layered Double Hydroxides-Hydroxyapatite/Gelatin Bone Tissue Engineering Scaffolds: Fabrication, Characterization, And In Vivo Study, Fateme Fayyazbakhsh, Mehran Solati-Hashjin, Abbas Keshtkar, Mohammad Ali Shokrgozar, Mohammad Mehdi Dehghan, Bagher Larijani
Novel Layered Double Hydroxides-Hydroxyapatite/Gelatin Bone Tissue Engineering Scaffolds: Fabrication, Characterization, And In Vivo Study, Fateme Fayyazbakhsh, Mehran Solati-Hashjin, Abbas Keshtkar, Mohammad Ali Shokrgozar, Mohammad Mehdi Dehghan, Bagher Larijani
Mechanical and Aerospace Engineering Faculty Research & Creative Works
Developing Porous Biodegradable Scaffolds through Simple Methods is One of the Main Approaches of Bone Tissue Engineering (BTE). in This Work, a Novel BTE Composite Containing Layered Double Hydroxides (LDH), Hydroxyapatite (HA) and Gelatin (GEL) Was Fabricated using Co-Precipitation and Solvent-Casting Methods. Physiochemical Characterizations Showed that the Chemical Composition and Microstructure of the Scaffolds Were Similar to the Natural Spongy Bone. Interconnected Macropores Ranging over 100 to 600 Μm Were Observed for Both Scaffolds While the Porosity of 90 ± 0.12% and 92.11 ± 0.15%, as Well As, Young's Modulus of 19.8 ± 0.41 and 12.5 ± 0.35 GPa Were …
On Demand 3d Printed Hybrid Scaffolds For Tissue Engineering Applications, Ivan D. Hernandez
On Demand 3d Printed Hybrid Scaffolds For Tissue Engineering Applications, Ivan D. Hernandez
Open Access Theses & Dissertations
A composite 3D printed polymer scaffold with inbuilt porosity and filled with a hydrogel can provide an ideal support system for cell growth, proliferation, and vascularization. Therefore, a hybrid system of 3D printed polycaprolactone (PCL) scaffold and a hydroxyapatite-based hydrogel was developed for application in the reconstruction of bone defects, which are inherently difficult to repair without any guided therapies. In the present study, a 3D printed gyroid structure of PCL allowed the loading of a higher amount of hydrogel as compared to conventionally used 3D printed mesh structure of the same volume and strut thickness. The hydrogel was composed …
Combination Of Bmp-2 And Relaxin To Induce Osteogenesis In Vivo, Sahitya Injamuri
Combination Of Bmp-2 And Relaxin To Induce Osteogenesis In Vivo, Sahitya Injamuri
Masters Theses
"Bone grafts are a common procedure for treating craniofacial injuries such as trauma, surgery, and reconstruction. Autografts and allografts have limitations which encourages the use of synthetic bone grafts. While synthetic bone grafts, such as hydroxyapatite (HA) microspheres, are advantageous for their cost and reproducibility, they lack the cells and growth factors needed for proper osteoinduction. Bone morphogenetic protein-2 (BMP-2) has been shown to increase the osteoinduction of grafts but the effective dose is above physiological levels and causes undesired effects on the body. Relaxin has been shown to enhance BMP-2's ability to induce bone formation in vitro and thus …