Engineering Commons^™

Modulation Of Cell Behaviors On Photo-Crosslinked Polymer Networks And Polymer Spherulites, Jinbo Dou

Doctoral Dissertations

This dissertation presents novel biodegradable and photo-crosslinkable poly(-caprolactone) acrylates (PCLAs) to achieve polymer networks with controllable surface chemistry, stiffness, and topographical features, as well as crystallization-induced PCL, poly(3-hydroxybutyrate) (PHB) and poly(L-lactic acid) (PLLA) surfaces for investigating cell-material interactions. Chapter I reviews the recent progress of injectable polymeric biomaterials in the last decade for various tissue engineering applications. Chapter II investigates the variation of thermal and mechanical properties of PCL triacrylate (PCLTA) networks with different crosslinking time, and further studies the smooth muscle cell (SMC) responses to these networks. Chapter III studies the SMC responses to hydrolyzed PCLTA/methoxyl polyethylene glycol monoacrylate …