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A Multicellular Model For Differential Regulation Of Circadian Signals In The Core And Shell Regions Of The Suprachiasmatic Nucleus, Christina Vasalou, Michael A. Henson
A Multicellular Model For Differential Regulation Of Circadian Signals In The Core And Shell Regions Of The Suprachiasmatic Nucleus, Christina Vasalou, Michael A. Henson
Michael A Henson
We developed a multicellular model of the mammalian circadian clock characterized by a high degree of heterogeneity with respect to single cell periodicity and behavior (intrinsic and driven oscillators), neurotransmitter release (VIP, GABA and glutamate synthesis) and spatial organization (core and shell regions), mimicking structural patterns within the SCN associated with distinct circadian functions. We simulated the SCN core and shell separately utilizing experimentally derived connectivity schemes for the two subdivisions as observed within the rat SCN. The core was modeled via a small world network characterized by VIP and GABA colocalization, whereas the shell was simulated as a nearest …