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Full-Text Articles in Engineering
Applications Of Diffusion Maps In Gene Expression Data-Based Cancer Diagnosis Analysis, Rui Xu, Donald C. Wunsch, Steven Damelin
Applications Of Diffusion Maps In Gene Expression Data-Based Cancer Diagnosis Analysis, Rui Xu, Donald C. Wunsch, Steven Damelin
Electrical and Computer Engineering Faculty Research & Creative Works
Early detection of a tumor's site of origin is particularly important for cancer diagnosis and treatment. The employment of gene expression profiles for different cancer types or subtypes has already shown significant advantages over traditional cancer classification methods. One of the major problems in cancer type recognition-oriented gene expression data analysis is the overwhelming number of measures of gene expression levels versus the small number of samples, which causes the curse of dimension issue. Here, we use diffusion maps, which interpret the eigenfunctions of Markov matrices as a system of coordinates on the original data set in order to obtain …
Classification Of Terahertz Data As A Tool For The Detection Of Cancer, Matthew J. Berryman, T. J. Rainsford
Classification Of Terahertz Data As A Tool For The Detection Of Cancer, Matthew J. Berryman, T. J. Rainsford
Faculty of Engineering - Papers (Archive)
The early detection of cancers is critical with respect to treatment and patient survival. Biopsy techniques that are currently employed for such diagnoses are invasive, time consuming and costly. A Terahertz (THz) imaging system potentially provides a fast and non-invasive way to detect and diagnose cancer. While there is proof of concept that THz can distinguish cancerous and normal tissue, the mechanisms underlying this differentiation are not well understood. A better understanding of THz spectral data can be gained through computational pattern recognition and related multivariate statistical tools. These allow for the differentiation of data into discrete and disjoint groups. …
Biochemical Characterization Of Htrf1 And Htep1, Two Proteins Involved In Telomere Maintenance, Kambiz Tahmaseb
Biochemical Characterization Of Htrf1 And Htep1, Two Proteins Involved In Telomere Maintenance, Kambiz Tahmaseb
Browse all Theses and Dissertations
Telomeres are the structures that protect the ends of linear chromosomes from fusion and degradation. The telomere consists of tandem repeated DNA sequences that can range from hundreds of bases to kilo-bases depending on the organism. As the cells of an organism replicate their DNA, these repeats are lost due to the end replication problem, where the ends of linear DNA cannot be fully replicated. As the telomeres are shortened through each round of replication, they eventually reach a critical point. Once the telomeres are too short and the cell risks losing coding sequences, a signaling pathway is initiated that …