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Development Of Novel Bio/Nano Interfaces For Materials Science And Biomedical Applications, Carlee Ashley
Development Of Novel Bio/Nano Interfaces For Materials Science And Biomedical Applications, Carlee Ashley
Chemical and Biological Engineering ETDs
Virus-like particles (VLPs) of MS2 bacteriophage possess a variety of characteristics that enable their use in biomedical and materials science applications. MS2 VLPs are perfectly monodisperse and possess a highly regular periodic structure. Their protein capsids can be modified in precise locations via chemical conjugation or genetic display of peptides, and their interior volumes can be readily loaded with a variety of non-genomic materials by taking advantage of their ability to self-assemble in the presence of RNA and RNA-modified cargos. Using peptides identified by filamentous phage display, I have demonstrated the utility of MS2 VLPs as targeted nanocarriers capable of …