Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Engineering
Biomimetic Poly(Ester Amide) Biomaterials For Vascular Tissue Engineering, Darryl K. Knight
Biomimetic Poly(Ester Amide) Biomaterials For Vascular Tissue Engineering, Darryl K. Knight
Electronic Thesis and Dissertation Repository
The focus of this research was to develop a biomimetic, degradable vascular scaffold that could be considered as part of a tissue-engineered vascular graft strategy. A family of degradable poly(ester amide)s (PEAs) derived from naturally occurring α-amino acids, aliphatic diols and diacids were synthesized to yield PEAs with glass transition temperatures below physiologic temperature ensuring their pliability. Tri-functional amino acids l-lysine or l-aspartic acid were incorporated into the polymer backbone yielding complementary functional handles for subsequent conjugation of growth factors. Higher molecular weight PEAs were obtained using an interfacial polycondensation technique compared with a solution polymerization approach.
Human coronary artery …
Sol-Gel Derived Biodegradable And Bioactive Organic-Inorganic Hybrid Biomaterials For Bone Tissue Engineering, Bedilu A. Allo
Sol-Gel Derived Biodegradable And Bioactive Organic-Inorganic Hybrid Biomaterials For Bone Tissue Engineering, Bedilu A. Allo
Electronic Thesis and Dissertation Repository
Treatments of bone injuries and defects have been largely centered on replacing the lost bone with tissues of allogeneic or xenogeneic sources as well as synthetic bone substitutes, which in all lead to limited degree of structural and functional recovery. As a result, tissue engineering has emerged as a viable technology to regenerate the structures and therefore recover the functions of bone tissue rather than replacement alone. Hence, the current strategies of bone tissue engineering and regeneration rely on bioactive scaffolds to mimic the natural extracellular matrix (ECM) as templates onto which cells attach, multiply, migrate and function.
In this …