Engineering Commons^™

Application Of Crystal Engineering In Multicomponent Pharmaceutical Crystals: A Study Of Theory And Practice, Soroush Ahmadi Nasrabadi

Electronic Thesis and Dissertation Repository

Multicomponent crystallization, a prominent strategy in crystal engineering, offers the ability to modify the physicochemical properties of crystals by introducing a secondary component to their lattice structure. Such multicomponent crystals have found widespread application in the pharmaceutical industry. This thesis explores the experimental screening, characterization, application, and theoretical prediction of multicomponent crystals of Active Pharmaceutical Ingredients (APIs).

The first case study investigates a new solvate of Dasatinib which exhibits high instability at room temperature and transforms into a different polymorph upon desolvation. The crystal structure of this compound is obtained, revealing insights into its transient nature and the potential application …

Ai Applications On Planetary Rovers, Alexis David Pascual

Electronic Thesis and Dissertation Repository

The rise in the number of robotic missions to space is paving the way for the use of artificial intelligence and machine learning in the autonomy and augmentation of rover operations. For one, more rovers mean more images, and more images mean more data bandwidth required for downlinking as well as more mental bandwidth for analyzing the images. On the other hand, light-weight, low-powered microrover platforms are being developed to accommodate the drive for planetary exploration. As a result of the mass and power constraints, these microrover platforms will not carry typical navigational instruments like a stereocamera or a laser …

Machine Learning With Big Data For Electrical Load Forecasting, Alexandra L'Heureux

Electronic Thesis and Dissertation Repository

Today, the amount of data collected is exploding at an unprecedented rate due to developments in Web technologies, social media, mobile and sensing devices and the internet of things (IoT). Data is gathered in every aspect of our lives: from financial information to smart home devices and everything in between. The driving force behind these extensive data collections is the promise of increased knowledge. Therefore, the potential of Big Data relies on our ability to extract value from these massive data sets. Machine learning is central to this quest because of its ability to learn from data and provide data-driven …

The Role Of Transient Vibration Of The Skull On Concussion, Rodrigo Dalvit Carvalho Da Silva

Electronic Thesis and Dissertation Repository

Concussion is a traumatic brain injury usually caused by a direct or indirect blow to the head that affects brain function. The maximum mechanical impedance of the brain tissue occurs at 450±50 Hz and may be affected by the skull resonant frequencies. After an impact to the head, vibration resonance of the skull damages the underlying cortex. The skull deforms and vibrates, like a bell for 3 to 5 milliseconds, bruising the cortex. Furthermore, the deceleration forces the frontal and temporal cortex against the skull, eliminating a layer of cerebrospinal fluid. When the skull vibrates, the force spreads directly to …

Leveraging Machine Learning Techniques Towards Intelligent Networking Automation, Cesar A. Gomez

Electronic Thesis and Dissertation Repository

In this thesis, we address some of the challenges that the Intelligent Networking Automation (INA) paradigm poses. Our goal is to design schemes leveraging Machine Learning (ML) techniques to cope with situations that involve hard decision-making actions. The proposed solutions are data-driven and consist of an agent that operates at network elements such as routers, switches, or network servers. The data are gathered from realistic scenarios, either actual network deployments or emulated environments. To evaluate the enhancements that the designed schemes provide, we compare our solutions to non-intelligent ones. Additionally, we assess the trade-off between the obtained improvements and the …

Optimized Machine Learning Models Towards Intelligent Systems, Mohammadnoor Ahmad Mohammad Injadat

Electronic Thesis and Dissertation Repository

The rapid growth of the Internet and related technologies has led to the collection of large amounts of data by individuals, organizations, and society in general [1]. However, this often leads to information overload which occurs when the amount of input (e.g. data) a human is trying to process exceeds their cognitive capacities [2]. Machine learning (ML) has been proposed as one potential methodology capable of extracting useful information from large sets of data [1]. This thesis focuses on two applications. The first is education, namely e-Learning environments. Within this field, this thesis proposes different optimized ML ensemble models to …