Engineering Commons^™

Bioactive And Electrically Conductive Nanocomposite Bone Biomaterials, Rebeca A. Arambula-Maldonado

Electronic Thesis and Dissertation Repository

Electrically conductive carbon-based materials are emerging as potential biomaterials for bone tissue engineering. Their incorporation into organic-inorganic nanocomposites mimics the structural composition and electrically conductive nature of bone.

The aim of this research was to design bone biomaterials from gelatin-based polymers, tertiary bioactive glasses (BG) via a sol-gel method, and multiwall carbon nanotubes (MWCNT). The incorporation of calcium into organic-inorganic nanocomposites plays an essential role in the development of bioactive bone biomaterials. Calcium chloride and calcium ethoxide were investigated as calcium sources in gelatin-BG-MWCNT nanocomposites. The resulting surface elemental distribution was homogeneous, but the swelling, degradation and porosity properties of …

Bioactive Glass-Ceramic Coating Of Titanium Substrates By Alkaline Hydrothermal Process, Mohamed Gebril

Electronic Thesis and Dissertation Repository

Surface modification is a well-known approach to enhance the osseointegration of titanium dental implants. In this study, a novel hydrothermal method for coating titanium surfaces with bioactive glass was developed. Our method included sol-gel synthesis of bioactive glass, followed by hydrothermal coating of titanium under different NaOH concentrations. The surface properties of coated substrates were evaluated by scanning electron microscopy, X-ray diffraction, energy dispersive X-ray spectroscopy, and surface profilometry. By varying the alkalinity of the hydrothermal process, different surface topographies, crystalline phases and chemistries could be obtained. Soaking the hydrothermally coated titanium substrates in simulated body fluid resulted in hydroxyapatite …

Sol-Gel Derived Biodegradable And Bioactive Organic-Inorganic Hybrid Biomaterials For Bone Tissue Engineering, Bedilu A. Allo

Electronic Thesis and Dissertation Repository

Treatments of bone injuries and defects have been largely centered on replacing the lost bone with tissues of allogeneic or xenogeneic sources as well as synthetic bone substitutes, which in all lead to limited degree of structural and functional recovery. As a result, tissue engineering has emerged as a viable technology to regenerate the structures and therefore recover the functions of bone tissue rather than replacement alone. Hence, the current strategies of bone tissue engineering and regeneration rely on bioactive scaffolds to mimic the natural extracellular matrix (ECM) as templates onto which cells attach, multiply, migrate and function.

In this …