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Reference Point Indentation Of Human Trabecular Bone Treated With Bisphosphonates For Varying Durations, Drew Jones
Reference Point Indentation Of Human Trabecular Bone Treated With Bisphosphonates For Varying Durations, Drew Jones
Theses and Dissertations--Biomedical Engineering
Reference point indentation (RPI), a novel form of micro-indentation, quantifies RPI material parameters which correlate with modulus, yield stress, strength, or toughness. Information linking bisphosphonate treatment length with the material properties of osteoporotic trabecular bone is needed to improve patient treatment. The objectives of this study were to: 1) determine if RPI can be used to successfully evaluate human trabecular bone and if so, determine an optimized test method for using RPI on trabecular bone, and 2) use this method to determine if any RPI parameters are related to the duration of bisphosphonate treatment.
Indentation using a 4 N applied …