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Airway Strain During Mechanical Ventilation In An Intact Animal Model, Scott W. Sinclair, Robert C. Molthen, Steven Thomas Haworth, Christopher A. Dawson, Christopher M. Waters
Airway Strain During Mechanical Ventilation In An Intact Animal Model, Scott W. Sinclair, Robert C. Molthen, Steven Thomas Haworth, Christopher A. Dawson, Christopher M. Waters
Biomedical Engineering Faculty Research and Publications
Rationale: Mechanical ventilation with large tidal volumes causes ventilator-induced lung injury in animal models. Little direct evidence exists regarding the deformation of airways in vivo during mechanical ventilation, or in the presence of positive end-expiratory pressure (PEEP).
Objectives: To measure airway strain and to estimate airway wall tension during mechanical ventilation in an intact animal model.
Methods: Sprague-Dawley rats were anesthetized and mechanically ventilated with tidal volumes of 6, 12, and 25 cm3/kg with and without 10–cm H2O PEEP. Real-time tantalum bronchograms were obtained for each condition, using microfocal X-ray imaging. Images were …