Engineering Commons^™

Prolonged Quadriceps Activity Following Imposed Hip Extension: A Neurophysiological Mechanism For Stiff-Knee Gait?, Michael D. Lewek, T. George Hornby, Yasin Y. Dhaher, Brian D. Schmit

Biomedical Engineering Faculty Research and Publications

The biomechanical characteristics of stiff knee gait following neurological injury include decreased knee flexion velocity at toe-off, which may be due to exaggerated quadriceps activity. The neuromuscular mechanism underlying this abnormal activity is unclear, although hyperexcitable heteronymous reflexes may be a source of impaired coordination. The present study examines the contribution of reflex activity from hip flexors on knee extensors following stroke and its association with reduced swing-phase knee flexion during walking. Twelve individuals poststroke and six control subjects were positioned in supine on a Biodex dynamometer with the ankle and knee held in a static position. Isolated hip extension …

Separate Adaptive Mechanisms For Controlling Trajectory And Final Position In Reaching, Robert A. Scheidt, Claude Ghez

Biomedical Engineering Faculty Research and Publications

We examined control of the hand's trajectory (direction and shape) and final equilibrium position in horizontal planar arm movements by quantifying transfer of learned visuomotor rotations between two tasks that required aiming the hand to the same spatial targets. In a trajectory-reversal task (“slicing”), the hand reversed direction within the target and returned to the origin. In a positioning task (“reaching”), subjects moved the hand to the target and held it there; cursor feedback was provided only after movement ended to isolate learning of final position from trajectory direction. We asked whether learning acquired in one task would transfer to …

Different Learned Coordinate Frames For Planning Trajectories And Final Positions In Reaching, Claude Ghez, Robert A. Scheidt, Hank Heijink

Biomedical Engineering Faculty Research and Publications

We previously reported that the kinematics of reaching movements reflect the superimposition of two separate control mechanisms specifying the hand's spatial trajectory and its final equilibrium position. We now asked whether the brain maintains separate representations of the spatial goals for planning hand trajectory and final position. One group of subjects learned a 30° visuomotor rotation about the hand's starting point while performing a movement reversal task (“slicing”) in which they reversed direction at one target and terminated movement at another. This task required accuracy in acquiring a target mid-movement. A second group adapted while moving to—and stabilizing at—a single …

Mechanical Behavior And Failure Analysis Of Prosthetic Retaining Screws After Long‐Term Use In Vivo. Part 1: Characterization Of Adhesive Wear And Structure Of Retaining Screws, Youssef S. Al Jabbari, Raymond Fournelle, Gerald J. Ziebert, Jeffrey M. Toth, Anthony Iacopino

Biomedical Engineering Faculty Research and Publications

Purpose: The general aim of this study and those presented in Parts 2–4 of this series was to characterize the structure, properties, wear, and fracture of prosthetic retaining screws in fixed detachable hybrid prostheses after long‐term use in vivo. This part of the overall investigation addresses whether there are differences in thread wear between the screws closest to the fulcrum and those that are farthest from the fulcrum in fixed detachable hybrid prostheses.

Materials and Methods: The total number of prosthetic retaining screws used in this study was 100 (10 new and 90 used). New screws (controls) from Nobel Biocare …

Mechanical Behavior And Failure Analysis Of Prosthetic Retaining Screws After Long‐Term Use In Vivo. Part 2: Metallurgical And Microhardness Analysis, Youssef S. Al Jabbari, Raymond Fournelle, Gerald J. Ziebert, Jeffrey M. Toth, Anthony Iacopino

Biomedical Engineering Faculty Research and Publications

Abstract

Purpose: This study involved testing and analyzing multiple retrieved prosthetic retaining screws after long‐term use in vivo to: (1) detect manufacturing defects that could affect in‐service behavior; (2) characterize the microstructure and alloy composition; and (3) further characterize the wear mechanism of the screw threads.

Materials and Methods: Two new (control) screws from Nobel Biocare (NB) and 18 used (in service 18–120 months) retaining screws [12 from NB and 6 from Sterngold (SG)] were: (1) metallographically examined by light microscopy and scanning electron microscopy (SEM) to determine the microstructure; (2) analyzed by energy dispersive X‐ray (EDX) microanalysis to determine …

Airway Strain During Mechanical Ventilation In An Intact Animal Model, Scott W. Sinclair, Robert C. Molthen, Steven Thomas Haworth, Christopher A. Dawson, Christopher M. Waters

Biomedical Engineering Faculty Research and Publications

Rationale: Mechanical ventilation with large tidal volumes causes ventilator-induced lung injury in animal models. Little direct evidence exists regarding the deformation of airways in vivo during mechanical ventilation, or in the presence of positive end-expiratory pressure (PEEP).

Objectives: To measure airway strain and to estimate airway wall tension during mechanical ventilation in an intact animal model.

Methods: Sprague-Dawley rats were anesthetized and mechanically ventilated with tidal volumes of 6, 12, and 25 cm³/kg with and without 10–cm H₂O PEEP. Real-time tantalum bronchograms were obtained for each condition, using microfocal X-ray imaging. Images were …

Chronic Hypoxia-Induced Pulmonary Hypertension Does/Does Not Lead To Loss Of Pulmonary Vasculature, Marlene Rabinovitch, Naomi Chesler, Robert C. Molthen

Biomedical Engineering Faculty Research and Publications

No abstract provided.

Rapid Detection Of Analytes With Improved Selectivity Using Coated Microcantilever Chemical Sensors And Estimation Theory, Michael J. Wenzel, Fabien Josse, Edwin E. Yaz, Stephen M. Heinrich, P. G. Datskos

Civil and Environmental Engineering Faculty Research and Publications

Rapid detection of analytes with improved selectivity is achieved though the use of estimation theory to analyze the response of polymer-coated microcantilever chemical sensors. In general, chemical sensors exhibit partial selectivity and can have relatively long response times. Using estimation theory, it is possible to make short-term response predictions from past data. This makes it possible to use the transient information (response time), often unique to an analyte/coating pair, to achieve an improvement in analyte species recognition while simultaneously allowing for a reduction in the time required for identification and quantification. An extended Kalman filter is used as a recursive …

Diagnosis Of Inter-Turn Short Circuit For A Polyphase Induction Motor In Closed-Loop Vector-Controlled Drives, Ahmed Sayed-Ahmed, Gennadi Y. Sizov, Nabeel Demerdash

Electrical and Computer Engineering Faculty Research and Publications

The main objective of this paper is to develop and experimentally verify a new technique to detect an inter-turn short circuit in one phase of a stator winding of an induction motor energized from a vector-controlled drive. This is in order to overcome the fault masking difficulties associated with the concept of depending on the actual magnetic field pendulous oscillation between the conventional voltage and current space vectors with respect to a reference that is unaltered by the compensation action of the drive. This technique is based on the flux pendulous oscillation phenomenon. This flux pendulous oscillation is also described …

A Light-Weight Event-Driven Protocol For Sensor Clustering In Wireless Camera Networks, Henry Medeiros, Johnny Park, Avinash Kak

Electrical and Computer Engineering Faculty Research and Publications

We propose a light-weight event-driven protocol for wireless camera networks to allow for formation and propagation of clusters of cameras for the purpose of collaborative processing during object tracking. Cluster formation is triggered by the detection of objects with specific features. Our protocol allows for simultaneous formation and propagation of multiple clusters. Cameras being directional devices, more than one cluster may track a single object since groups of cameras outside each others communication range may see the same object. Entry into a cluster and cluster membership maintenance require a sensor node to confirm the presence of features of the object …

Role Of Mitochondrial Electron Transport Complex I In Coenzyme Q1 Reduction By Intact Pulmonary Arterial Endothelial Cells And The Effect Of Hyperoxia, Marilyn P. Merker, Said H. Audi, Brian J. Lindemer, Gary S. Krenz, Robert D. Bongard

Biomedical Engineering Faculty Research and Publications

The objective was to determine the impact of intact normoxic and hyperoxia-exposed (95% O(2) for 48 h) bovine pulmonary arterial endothelial cells in culture on the redox status of the coenzyme Q(10) homolog coenzyme Q(1) (CoQ(1)). When CoQ(1) (50 microM) was incubated with the cells for 30 min, its concentration in the medium decreased over time, reaching a lower level for normoxic than hyperoxia-exposed cells. The decreases in CoQ(1) concentration were associated with generation of CoQ(1) hydroquinone (CoQ(1)H(2)), wherein 3.4 times more CoQ(1)H(2) was produced in the normoxic than hyperoxia-exposed cell medium (8.2 +/- 0.3 and 2.4 +/- 0.4 microM, …

Marquette Interchange Phase I Final Report, Nicholas Hornyak, James Crovetti, David Newman, Jay Schabelski

Transportation Research Center: Marquette Interchange Instrumentation

This report provides details on the design, installation and monitoring of a pavement instrumentation system for the analysis of load-induced stresses and strains within a perpetual HMA pavement system. The HMA pavement was constructed as part of an urban highway improvement project in the City of Milwaukee, Wisconsin. The outer wheel path of the outside lane was instrumented with asphalt strain sensors, base and subgrade pressure sensors, subgrade moisture and temperature sensors, HMA layer temperature sensors, traffic wander strips and a weigh in motion system. Environmental sensors for air temperature, wind speed and solar radiation are also included. The system …

Pulmonary Microvascular Injury Resulting From A Single Exposure To Low-Dose Thoracic Radiation, Q. Wu, G. Schmirler, John E. Moulder, Elizabeth R. Jacobs, Meetha Medhora, Robert C. Molthen

Biomedical Engineering Faculty Research and Publications

No abstract provided.

Soleus H-Reflex Excitability Changes In Response To Sinusoidal Hip Stretches In The Injured Human Spinal Cord, Maria Knikou, Brian D. Schmit, Debjani Chaudhuri, Elizabeth Kay, William Zev Rymer

Biomedical Engineering Faculty Research and Publications

Imposed static hip stretches substantially modulate the soleus H-reflex in people with an intact or injured spinal cord while stretch of the hip flexors affect the walking pattern in lower vertebrates and humans. The aim of this study was to assess the effects of dynamic hip stretches on the soleus H-reflex in supine spinal cord injured (SCI) subjects. Sinusoidal movements were imposed on the right hip joint at 0.2 Hz by a Biodex system. H-reflexes from the soleus muscle were recorded as the leg moved in flexion or extension. Stimuli were sent only once in every hip movement cycle that …

D-4f Does Not Mitigate Key Parameters In Rat Model Of Severe Pulmonary Hypertension, Robert C. Molthen, Shelley Baumgardt, K. A. Pritchard Jr

Biomedical Engineering Faculty Research and Publications

No abstract provided.

Design And Validation Of A Mr-Compatible Pneumatic Manipulandum, Aaron J. Suminski, Janice L. Zimbelman, Robert A. Scheidt

Biomedical Engineering Faculty Research and Publications

The combination of functional MR imaging and novel robotic tools may provide unique opportunities to probe the neural systems underlying motor control and learning. Here, we describe the design and validation of a MR-compatible, 1 degree-of-freedom pneumatic manipulandum along with experiments demonstrating its safety and efficacy. We first validated the robot's ability to apply computer-controlled loads about the wrist, demonstrating that it possesses sufficient bandwidth to simulate torsional spring-like loads during point-to-point flexion movements. Next, we verified the MR-compatibility of the device by imaging a head phantom during robot operation. We observed no systematic differences in two measures of MRI …

Robust Minimum Variance Linear State Estimators For Multiple Sensors With Different Failure Rates, Franck O. Hounkpevi, Edwin E. Yaz

Electrical and Computer Engineering Faculty Research and Publications

Linear minimum variance unbiased state estimation is considered for systems with uncertain parameters in their state space models and sensor failures. The existing results are generalized to the case where each sensor may fail at any sample time independently of the others. For robust performance, stochastic parameter perturbations are included in the system matrix. Also, stochastic perturbations are allowed in the estimator gain to guarantee resilient operation. An illustrative example is included to demonstrate performance improvement over the Kalman filter which does not include sensor failures in its measurement model.

Parallel Facilitatory Reflex Pathways From The Foot And Hip To Flexors And Extensors In The Injured Human Spinal Cord, Maria Knikou, Elizabeth Kay, Brian D. Schmit

Biomedical Engineering Faculty Research and Publications

Spinal integration of sensory signals associated with hip position, muscle loading, and cutaneous sensation of the foot contributes to movement regulation. The exact interactive effects of these sensory signals under controlled dynamic conditions are unknown. The purpose of the present study was to establish the effects of combined plantar cutaneous afferent excitation and hip movement on the Hoffmann (H) and flexion reflexes in people with a spinal cord injury (SCI). The flexion and H-reflexes were elicited through stimulation of the right sural (at non-nociceptive levels) and posterior tibial nerves respectively. Reflex responses were recorded from the ipsilateral tibialis anterior (TA) …

Generalized Characteristics Of Resonant Polymer-Coated Microcantilevers In Viscous Liquid Media, Russell Cox, Michael J. Wenzel, Fabien Josse, Stephen M. Heinrich, Isabelle Dufour

Civil and Environmental Engineering Faculty Research and Publications

Expressions describing the resonant frequency and quality factor of a dynamically-driven, polymer-coated microcantilever in a viscous liquid medium have been obtained. These generalized formulas are used to describe the effects the operational medium and the coating has on the device sensitivity when used in liquid-phase chemical sensing applications. The derived expressions are shown to reduce to well-known formulas for the case of an uncoated cantilever in an invisicid [sic] medium and the case of a coated cantilever in air. The theoretical results are compared to existing chemical sensor data in aqueous and viscous solutions.

Stress And Emotion Classification Using Jitter And Shimmer Features, Xi Li, Jidong Tao, Michael T. Johnson, Joseph Soltis, Anne Savage, Kirsten Leong, John D. Newman

Dr. Dolittle Project: A Framework for Classification and Understanding of Animal Vocalizations

In this paper, we evaluate the use of appended jitter and shimmer speech features for the classification of human speaking styles and of animal vocalization arousal levels. Jitter and shimmer features are extracted from the fundamental frequency contour and added to baseline spectral features, specifically Mel-frequency cepstral coefficients (MFCCs) for human speech and Greenwood function cepstral coefficients (GFCCs) for animal vocalizations. Hidden Markov models (HMMs) with Gaussian mixture models (GMMs) state distributions are used for classification. The appended jitter and shimmer features result in an increase in classification accuracy for several illustrative datasets, including the SUSAS dataset for human speaking …

Reach Adaptation And Final Position Control Amid Environmental Uncertainty After Stroke, Robert A. Scheidt, Tina M. Stoeckmann

Biomedical Engineering Faculty Research and Publications

We characterized how hemiparetic stroke survivors and neurologically intact individuals adapt reaching movements to compensate for unpredictable environmental perturbations. We tested the hypotheses that like unimpaired subjects, hemiparetic stroke survivors adapt using sensory information obtained during only the most recent movements and that the reliability of target acquisition decreases as the degree of sensorimotor impairment increases. Subjects held the handle of a two-joint robotic arm that applied forces to the hand while reaching between targets in a horizontal plane. The robot simulated a dynamic environment that varied randomly in strength from one trial to the next. The trial sequence of …

Intelligent Painting Process Planner For Robotic Bridge Painting, Yong Bai

Civil and Environmental Engineering Faculty Research and Publications

Due to increased government regulations on environment, health, and safety, the cost of on-site bridge painting has quadrupled over the past several years. The construction industry faces a great challenge in how to control the increased costs of bridge painting and meet the regulations at the same time. A possible solution to address this challenge is to develop a robotic bridge painting system. The development of the robotic system can be justified by the potential improvements in safety and productivity. This paper presents the development and testing of an Intelligent Painting Process Planner. The Planner, built based on bridge feature …

In Vitro Cell Culture Infectivity Assay For Human Noroviruses, Timothy M. Straub, Kerstin Höner Zu Bentrup, Patricia Orosz Coghlan, Alice Dohnalkova, Brooke K. Mayer, Rachel A. Bartholomew, Catherine O. Valdez, Cynthia J. Bruckner-Lea, Charles P. Gerba, Morteza A. Abbaszadegan, Cheryl A. Nickerson

Civil and Environmental Engineering Faculty Research and Publications

Human noroviruses cause severe, self-limiting gastroenteritis that typically lasts 24–48 hours. Because of the lack of suitable tissue culture or animal models, the true nature of norovirus pathogenesis remains unknown. We show that noroviruses can infect and replicate in a 3-dimensional (3-D), organoid model of human small intestinal epithelium. Cells grown on porous collage-coated beads under fluid shear conditions in rotating wall vessel bioreactors differentiate into 3-D architectures resembling both the morphologic and physiologic function of in vivo tissues. Microscopy, PCR, and fluorescent in situ hybridization provided evidence of norovirus infection. Cytopathic effect and norovirus RNA were detected at each …

Speech Signal Enhancement Through Adaptive Wavelet Thresholding, Michael T. Johnson, Xiaolong Yuan, Yao Ren

Electrical and Computer Engineering Faculty Research and Publications

This paper demonstrates the application of the Bionic Wavelet Transform (BWT), an adaptive wavelet transform derived from a non-linear auditory model of the cochlea, to the task of speech signal enhancement. Results, measured objectively by Signal-to-Noise ratio (SNR) and Segmental SNR (SSNR) and subjectively by Mean Opinion Score (MOS), are given for additive white Gaussian noise as well as four different types of realistic noise environments. Enhancement is accomplished through the use of thresholding on the adapted BWT coefficients, and the results are compared to a variety of speech enhancement techniques, including Ephraim Malah filtering, iterative Wiener filtering, and spectral …

Neural And Electromyographic Correlates Of Wrist Posture Control, Aaron J. Suminski, Stephen M. Rao, Kristine M. Mosier, Robert A. Scheidt

Biomedical Engineering Faculty Research and Publications

In identical experiments in and out of a MR scanner, we recorded functional magnetic resonance imaging and electromyographic correlates of wrist stabilization against constant and time-varying mechanical perturbations. Positioning errors were greatest while stabilizing random torques. Wrist muscle activity lagged changes in joint angular velocity at latencies suggesting trans-cortical reflex action. Drift in stabilized hand positions gave rise to frequent, accurately directed, corrective movements, suggesting that the brain maintains separate representations of desired wrist angle for feedback control of posture and the generation of discrete corrections. Two patterns of neural activity were evident in the blood-oxygenation-level-dependent (BOLD) time series …

Theoretical Analysis Of Strong-Axis Bending Mode Vibrations For Resonant Microcantilever (Bio)Chemical Sensors In Gas Or Liquid Phase, Isabelle Dufour, Stephen M. Heinrich, Fabien Josse

Civil and Environmental Engineering Faculty Research and Publications

The frequency stability, sensitivity, and limit of detection of a coated-cantilever chemical sensor operating in a dynamic mode are mainly determined by its mechanical quality factor. While a coated-cantilever operating in the gas phase exhibits a large reduction in quality factor, immersion in liquids results in an even greater reduction in the Q-factor due to displaced fluid mass and losses in the surrounding liquid. In this paper, two different bending vibration modes are studied in order to minimize both the losses induced by the surrounding medium and the displaced fluid mass, thus increasing the quality factor and sensitivity and improving …

Effect Of Coating Viscoelasticity On Quality Factor And Limit Of Detection Of Microcantilever Chemical Sensors, Isabelle Dufour, Frederic Lochon, Stephen M. Heinrich, Fabien Josse, Dominique Rebiere

Civil and Environmental Engineering Faculty Research and Publications

Microcantilevers with polymer coatings hold great promise as resonant chemical sensors. It is known that the sensitivity of the coated cantilever increases with coating thickness; however, increasing this thickness also results in an increase of the frequency noise due to a decrease of the quality factor. By taking into account only the losses associated with the silicon beam and the surrounding medium, the decrease of the quality factor cannot be explained. In this paper, an analytical expression is obtained for the quality factor, which accounts for viscoelastic losses in the coating. This expression explains the observed decrease of the quality …

Effects Of Subsurface Drainage On Pavement Performance, James Crovetti, Kathleen T. Hall

Transportation Reports with the Wisconsin Department of Transportation

This report evaluates the effects of subsurface drainage features on pavement performance through a program of inspection and testing of the subsurface drainage features present in the Long-Term Pavement Performance (LTPP) SPS-1 and SPS-2 field sections. The report will be of particular interest to engineers in the public and private sectors with responsibility for the design, construction, and rehabilitation of highway pavements.

Quantifying Kinematics Of Purposeful Movements To Real, Imagined, Or Absent Functional Objects: Implications For Modelling Trajectories For Robot-Assisted Adl Tasks, Kimberly J. Wisneski, Michelle J. Johnson

Biomedical Engineering Faculty Research and Publications

Background

Robotic therapy is at the forefront of stroke rehabilitation. The Activities of Daily Living Exercise Robot (ADLER) was developed to improve carryover of gains after training by combining the benefits of Activities of Daily Living (ADL) training (motivation and functional task practice with real objects), with the benefits of robot mediated therapy (repeatability and reliability). In combining these two therapy techniques, we seek to develop a new model for trajectory generation that will support functional movements to real objects during robot training. We studied natural movements to real objects and report on how initial reaching movements are affected by …

Potential Of A Suite Of Robot/Computer-Assisted Motivating Systems For Personalized, Home-Based, Stroke Rehabilitation, Michelle J. Johnson, Xin Feng, Laura M. Johnson, Jack M. Winters

Electrical and Computer Engineering Faculty Research and Publications

Background

There is a need to improve semi-autonomous stroke therapy in home environments often characterized by low supervision of clinical experts and low extrinsic motivation. Our distributed device approach to this problem consists of an integrated suite of low-cost robotic/computer-assistive technologies driven by a novel universal access software framework called UniTherapy. Our design strategy for personalizing the therapy, providing extrinsic motivation and outcome assessment is presented and evaluated.

Methods

Three studies were conducted to evaluate the potential of the suite. A conventional force-reflecting joystick, a modified joystick therapy platform (TheraJoy), and a steering wheel platform (TheraDrive) were tested separately with …