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Articles 1 - 13 of 13
Full-Text Articles in Engineering
PdmsStar-Peg Hydrogels Prepared Via Solvent-Induced Phase Separation (Sips) And Their Potential Utility As Tissue Engineering Scaffolds, B. M. Bailey, R. Fei, Dany J. Munoz Pinto, M. S. Hahn, M. A. Grunlan
PdmsStar-Peg Hydrogels Prepared Via Solvent-Induced Phase Separation (Sips) And Their Potential Utility As Tissue Engineering Scaffolds, B. M. Bailey, R. Fei, Dany J. Munoz Pinto, M. S. Hahn, M. A. Grunlan
Dany J. Munoz Pinto
Inorganic-organic hydrogels based on methacrylated star polydimethylsiloxane (PDMSstar-MA) and diacrylated poly(ethylene glycol) (PEG-DA) macromers were prepared via solvent-induced phase separation (SIPS). The macromers were combined in a dichloromethane precursor solution and sequentially photopolymerized, dried and hydrated. The chemical and physical properties of the hydrogels were further tailored by varying the number average molecular weight (Mn) of PEG-DA (Mn = 3.4k and 6k g mol-1) as well as the weight percent ratio of PDMSstar-MA (Mn = 7k g mol-1) to PEG-DA from 0:100 to 20:80. Compared to analogous hydrogels …
Characterization Of Sequential Collagen-Poly(Ethylene Glycol) Diacrylate Interpenetrating Networks And Initial Assessment Of Their Potential For Vascular Tissue Engineering, Dany J. Munoz Pinto, Andrea C. Jimenez-Vergara, T. P. Gharat, M. S. Hahn
Characterization Of Sequential Collagen-Poly(Ethylene Glycol) Diacrylate Interpenetrating Networks And Initial Assessment Of Their Potential For Vascular Tissue Engineering, Dany J. Munoz Pinto, Andrea C. Jimenez-Vergara, T. P. Gharat, M. S. Hahn
Dany J. Munoz Pinto
Collagen hydrogels have been widely investigated as scaffolds for vascular tissue engineering due in part to the capacity of collagen to promote robust cell adhesion and elongation. However, collagen hydrogels display relatively low stiffness and strength, are thrombogenic, and are highly susceptible to cell-mediated contraction. In the current work, we develop and characterize a sequentially-formed interpenetrating network (IPN) that retains the benefits of collagen, but which displays enhanced mechanical stiffness and strength, improved thromboresistance, high physical stability and resistance to contraction. In this strategy, we first form a collagen hydrogel, infuse this hydrogel with poly(ethylene glycol) diacrylate (PEGDA), and subsequently …
Tissue Engineering Scaffolds With Enhanced Oxygen Delivery Using A Cyclodextrin Inclusion Complex, Tierney Gb Deluzio
Tissue Engineering Scaffolds With Enhanced Oxygen Delivery Using A Cyclodextrin Inclusion Complex, Tierney Gb Deluzio
Tierney GB Deluzio
The development of a strategy to improve oxygen delivery to cells seeded on scaffolds is essential for the success of tissue engineering applications. The focus of this work was to explore the application of cyclodextrin inclusion complexes (CD:ICs) with perfluorocarbons as oxygen carriers. CD:ICs were prepared from alpha-cyclodextrin and perfluoroperhydrophenanthrene via co-precipitation, paste mixing, and dry mixing complexation techniques. Characterization indicated that paste mixing at a 2:1 host:guest ratio was the most effective method for complexation between the parent molecules. The CD:ICs were then successfully incorporated in 3D fibrous mats via electrospinning with poly(carbonate urethane) and polycaprolactone as biostable and …
Nanoparticles For Stem-Cell Engineering, Esmaiel Jabbari
Nanoparticles For Stem-Cell Engineering, Esmaiel Jabbari
Esmaiel Jabbari
No abstract provided.
Osteogenic Differentiation Of Mesenchymal Stem Cells On Novel Three-Dimensional Poly(L-Lactic Acid)/Chitosan/Gelatin/Β-Tricalcium Phosphate Hybrid Scaffolds, Yousef Mohammadi, Hamid Mirzadeh, Fathollah Moztarzadeh, Masoud Soleimani, Esmaiel Jabbari
Osteogenic Differentiation Of Mesenchymal Stem Cells On Novel Three-Dimensional Poly(L-Lactic Acid)/Chitosan/Gelatin/Β-Tricalcium Phosphate Hybrid Scaffolds, Yousef Mohammadi, Hamid Mirzadeh, Fathollah Moztarzadeh, Masoud Soleimani, Esmaiel Jabbari
Esmaiel Jabbari
No abstract provided.
Synthesis, Material Properties, And Biocompatibility Of A Novel Self-Cross-Linkable Poly(Caprolactone Fumarate) As An Injectable Tissue Engineering Scaffold, Esmaiel Jabbari, Shanfeng Wang, Lichun Lu, James Gruetzmacher, Syed Ameenuddin, Theresa Hefferan, Bradford Currier, Anthony Windebank, Michael Yaszemski
Synthesis, Material Properties, And Biocompatibility Of A Novel Self-Cross-Linkable Poly(Caprolactone Fumarate) As An Injectable Tissue Engineering Scaffold, Esmaiel Jabbari, Shanfeng Wang, Lichun Lu, James Gruetzmacher, Syed Ameenuddin, Theresa Hefferan, Bradford Currier, Anthony Windebank, Michael Yaszemski
Esmaiel Jabbari
No abstract provided.
Implantable Polymer/Metal Thin Film Structures For The Localized Treatment Of Cancer By Joule Heating, Nima Rahbar, Kwabena Kan-Dapaah, Christian Theriault, Wole Soboyejo
Implantable Polymer/Metal Thin Film Structures For The Localized Treatment Of Cancer By Joule Heating, Nima Rahbar, Kwabena Kan-Dapaah, Christian Theriault, Wole Soboyejo
Nima Rahbar
This paper presents an implantable polymer/metal alloy thin film structure for localized post-operative treatment of breast cancer. A combination of experiments and models is used to study the temperature changes due to Joule heating by patterned metallic thin films embedded in poly-dimethylsiloxane. The heat conduction within the device and the surrounding normal/cancerous breast tissue is modeled with three-dimensional finite element method (FEM). The FEM simulations are used to explore the potential effects of device geometry and Joule heating on the temperature distribution and lesion (thermal dose). The FEM model is validated using a gel model that mimics biological media. The …
Electrospinning For Tissue Engineering Scaffolds, J. Lannutti, Darrell Reneker, T. Ma, D. Tomasko, D. Farson
Electrospinning For Tissue Engineering Scaffolds, J. Lannutti, Darrell Reneker, T. Ma, D. Tomasko, D. Farson
Darrell Hyson Reneker
Tissue engineering involves fabrication of three-dimensional scaffolds to support cellular in-growth and proliferation. The goal: generation of ‘neotissues’ that the body can adapt to carry out physiological function. To achieve this generation of scaffolds having tailored, biomimetic (across multiple scales) geometries has become important. The functional complexity of electrospun scaffolds provides significant advantages over other techniques; however, improvements are required before optimal utilization in vivo becomes routine. Cells on such surfaces are sensitive to topography. Electrospinning can be altered to influence either (1) the surface topography of the fibers themselves or (2) the larger topography of the ‘web’ of spun …
Development And Characterization Of A 3d Multicell Microtissue Culture Model Of Airway Smooth Muscle., Glenn Gaudette, Adrian West, Nishat Zaman, Darren Cole, Matthew Walker, Wesley Legant, Thomas Boudou, Christopher Chen, John Favreau, Elizabeth Cowley, Geoffrey Maksym
Development And Characterization Of A 3d Multicell Microtissue Culture Model Of Airway Smooth Muscle., Glenn Gaudette, Adrian West, Nishat Zaman, Darren Cole, Matthew Walker, Wesley Legant, Thomas Boudou, Christopher Chen, John Favreau, Elizabeth Cowley, Geoffrey Maksym
Glenn R. Gaudette
Airway smooth muscle (ASM) cellular and molecular biology is typically studied with single-cell cultures grown on flat 2D substrates. However, cells in vivo exist as part of complex 3D structures, and it is well established in other cell types that altering substrate geometry exerts potent effects on phenotype and function. These factors may be especially relevant to asthma, a disease characterized by structural remodeling of the airway wall, and highlights a need for more physiologically relevant models of ASM function. We utilized a tissue engineering platform known as microfabricated tissue gauges to develop a 3D culture model of ASM featuring …
Biomaterial-Microvasculature Interactions, Alisha Sarang-Sieminski, Keith Gooch
Biomaterial-Microvasculature Interactions, Alisha Sarang-Sieminski, Keith Gooch
Alisha L. Sarang-Sieminski
The utility of implanted sensors, drug-delivery systems, immunoisolation devices, engineered cells, and engineered tissues can be limited by inadequate transport to and from the circulation. As the primary function of the microvasculature is to facilitate transport between the circulation and the surrounding tissue, interactionsbetween biomaterials and the microvasculature have been explored to understand the mechanisms controlling transport to implanted objects and ultimately improve it. This review surveys work on biomaterial-microvasculature interactions with a focus on the use of biomaterials to regulate the structure and function of the microvasculature. Several applications in which biomaterial-microvasculature interactions play a crucial role are briefly …
Biomaterial–Microvasculature Interactions, Alisha L. Sarang-Sieminski, Keith J. Gooch
Biomaterial–Microvasculature Interactions, Alisha L. Sarang-Sieminski, Keith J. Gooch
Alisha L. Sarang-Sieminski
The utility of implanted sensors, drug-delivery systems, immunoisolation devices, engineered cells, and engineered tissues can be limited by inadequate transport to and from the circulation. As the primary function of the microvasculature is to facilitate transport between the circulation and the surrounding tissue, interactions between biomaterials and the microvasculature have been explored to understand the mechanisms controlling transport to implanted objects and ultimately improve it. This review surveys work on biomaterial–microvasculature interactions with a focus on the use of biomaterials to regulate the structure and function of the microvasculature. Several applications in which biomaterial–microvasculature interactions play a crucial role are …
Photo-Cross-Linked Pdmsstar-Peg Hydrogels: Synthesis, Characterization, And Potential Application For Tissue Engineering Scaffolds, Yaping Hou, Cody Schoener, Katherine Regan, Dany Munoz Pinto, Mariah Hahn, Melissa Grunlan
Photo-Cross-Linked Pdmsstar-Peg Hydrogels: Synthesis, Characterization, And Potential Application For Tissue Engineering Scaffolds, Yaping Hou, Cody Schoener, Katherine Regan, Dany Munoz Pinto, Mariah Hahn, Melissa Grunlan
Dany J. Munoz Pinto
Inorganic−organic hydrogels with tunable chemical and physical properties were prepared from methacrylated star polydimethylsiloxane (PDMSstar-MA) and diacrylated poly(ethylene glycol) (PEG-DA) for use as tissue engineering scaffolds. A total of 18 compositionally unique hydrogels were prepared by photo-cross-linking, varying weight ratios of PEG-DA and PDMSstar-MA of different molecular weights (Mn): PEG-DA (Mn = 3.4k and 6k g/mol) and PDMSstar-MA (Mn = 1.8k, 5k, and 7k g/mol). Introduction of PDMSstar-MA caused formation of discrete PDMS-enriched microparticles dispersed within the PEG matrix. The swelling ratio, mechanical properties in tension and compression, nonspecific protein adhesion, controlled introduction of bioactivity, and cytotoxicity of hydrogels were …
Influence Of Hydrogel Mechanical Properties And Mesh Size On Vocal Fold Fibroblast Extracellular Matrix Production And Phenotype, Huimin Liao, Dany Munoz Pinto, Xin Qu, Yaping Hou, Melissa Grunlan, Mariah Hahn
Influence Of Hydrogel Mechanical Properties And Mesh Size On Vocal Fold Fibroblast Extracellular Matrix Production And Phenotype, Huimin Liao, Dany Munoz Pinto, Xin Qu, Yaping Hou, Melissa Grunlan, Mariah Hahn
Dany J. Munoz Pinto
Current clinical management of vocal fold (VF) scarring produces inconsistent and often suboptimal results. Researchers are investigating a number of alternative treatments for VF lamina propria (LP) scarring, including designer implant materials for functional LP regeneration. In the present study, we investigate the effects of the initial scaffold elastic modulus and mesh size on encapsulated VF fibroblast (VFF) extracellular matrix (ECM) production toward rational scaffold design. Poly(ethylene glycol) diacrylate (PEGDA) hydrogels were selected for this study since their material properties, including mechanical properties, mesh size, degradation rate and bioactivity, can be tightly controlled and systematically modified. Porcine VFF were encapsulated …