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Full-Text Articles in Engineering
3d Cell Culture: Techniques, Applications In Healthcare, And Future Challenges, Mukunthan K S
3d Cell Culture: Techniques, Applications In Healthcare, And Future Challenges, Mukunthan K S
Manipal Journal of Science and Technology
Two-dimensional (2D) cell cultures have been the most commonly used technique since cell culture was first introduced. However, these cultures do not accurately represent animal physiology as many factors that play an important role in the growth of animal cells are overlooked. Three-dimensional (3D) cell culture techniques provide higher accuracy in recreating the microenvironment of native tissues. But, 2D cell culture techniques are still preferred for the majority of animal cell cultures as these are well established and relatively inexpensive. Various techniques have been developed for 3D cell culture but these systems are highly complex as the number of parameters …
Encapsulating Liposomes For Stabilized Drug Delivery, Corbin Jacobs, Dr. William Pitt
Encapsulating Liposomes For Stabilized Drug Delivery, Corbin Jacobs, Dr. William Pitt
Journal of Undergraduate Research
Liposomes are tiny vesicles composed of materials similar to a cell membrane’s bilayer and “are useful for delivering anticancer agents to tumors and reducing the severe side effects of the agents.”1 Following synthesis, liposomes containing drug are administered intravenously. Fortunately, tumors have hyperpermeable vasculature which facilitates liposomal accumulation by their leaking out of the capillaries surrounding the tumor.2 Once near the tumor, individual cells will endocytose or engulf the vesicles as long as they are between 10 nm and 1000 nm.3
Interaction Of Liposomal Drug Delivery Systems With Cells And Tissues: Microscopic Studies, M. Foldvari, G. T. Faulkner, C. Mezei, M. Mezei
Interaction Of Liposomal Drug Delivery Systems With Cells And Tissues: Microscopic Studies, M. Foldvari, G. T. Faulkner, C. Mezei, M. Mezei
Cells and Materials
Liposomes , as drug carriers, can be administered into the body by several routes e.g. intravenously, intraperitoneally, intramuscularly, intratracheally and topically among others. Radiolabelled markers are suitable to monitor the distribution and elimination of liposomes, but the tissue deposition of intact liposomes, the mode and sites of drug release from the liposomes and liposome-cell interactions cannot be investigated morphologically. Microscopic techniques could provide information regarding the intact state of liposomes and possibly the dynamics of liposomes in tissues provided that they can be identified with certainty in vivo. This is a formidable problem and in spite of several attempts, there …