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Full-Text Articles in Engineering

Assembly Of Nucleic Acid-Based Nanoparticles By Gas-Liquid Segmented Flow Microfluidics, Matthew L. Capek, Ross Verheul, David H. Thompson Aug 2016

Assembly Of Nucleic Acid-Based Nanoparticles By Gas-Liquid Segmented Flow Microfluidics, Matthew L. Capek, Ross Verheul, David H. Thompson

The Summer Undergraduate Research Fellowship (SURF) Symposium

The development of novel and efficient mixing methods is important for optimizing the efficiency of many biological and chemical processes. Tuning the physical and performance properties of nucleic acid-based nanoparticles is one such example known to be strongly affected by mixing efficiency. The characteristics of DNA nanoparticles (such as size, polydispersity, ζ-potential, and gel shift) are important to ensure their therapeutic potency, and new methods to optimize these characteristics are of significant importance to achieve the highest efficacy. In the present study, a simple segmented flow microfluidics system has been developed to augment mixing of pDNA/bPEI nanoparticles. This DNA and …


Effect Of Aggregation And Particle Size On The Thermal Conductivity Of Nickel-Epoxy Nanocomposites, Jacob M. Faulkner, Xiangyu Li, Xiulin Ruan Dr. Aug 2016

Effect Of Aggregation And Particle Size On The Thermal Conductivity Of Nickel-Epoxy Nanocomposites, Jacob M. Faulkner, Xiangyu Li, Xiulin Ruan Dr.

The Summer Undergraduate Research Fellowship (SURF) Symposium

Microprocessor advancements have been stunted in recent years by inadequate means of heat dissipation as power continues to grow and size continues to shrink. One way to increase thermal conductivity while maintaining electrical insulation is to add metal nanoparticles to a polymer matrix. This cheap material has become a popular thermal interface for this reason. However, optimization of the interface is dependent upon a number of factors including particle size, shape, orientation, and aggregation. Various theoretical models and numerical approximations have been developed to find the effective thermal conductivity of such nanocomposites, but none has been able to fully incorporate …