Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Engineering
An Engineer’S Take On The Bone-Ligament Interface: Utilizing Novel Technology To Improve Clinical Outcomes, Emma Garcia
An Engineer’S Take On The Bone-Ligament Interface: Utilizing Novel Technology To Improve Clinical Outcomes, Emma Garcia
Shared Knowledge Conference
Ligament repair is a common surgical practice with a significant lack of viable replacements. The current gold standard for repair is the use of tendon grafts from cadavers or from another place in the patient’s body; however, these often cause more problems than they solve including immune responses or a lack of mobility in another place in the body. Synthetic replacements are of growing interest, though the ability to mimic the complex structure of the ligament and how it connects to the bone remains an obstacle. Our lab built a 3D bioprinter combined with an electrospinner to address this complicated …
3d Bioprinting And Near-Field Electrospinning Composite Scaffolds For The Bone-Ligament Interface, Emma Garcia, Christina Salas, Matthew N. Rush, Christopher Buksa, Marissa Perez, Ava Mauser, Steven Nery, Fermin Prieto, Darielys Morales
3d Bioprinting And Near-Field Electrospinning Composite Scaffolds For The Bone-Ligament Interface, Emma Garcia, Christina Salas, Matthew N. Rush, Christopher Buksa, Marissa Perez, Ava Mauser, Steven Nery, Fermin Prieto, Darielys Morales
Shared Knowledge Conference
3D bioprinting is an additive manufacturing technique that can utilize a range of bioactive materials to construct specific architectures that mimic native tissue. Near-field electrospinning (NFE) offers precise alignment control to create non-woven mats with high tensile strengths. We built a custom E-spin printer that enables layer-by-layer alternating deposition between 3D bioprinting and NFE to create composite scaffolds for the bone-ligament interface. This complex region is difficult to simulate due to its functionally graded mechanical and biochemical properties. We created NFE poly(caprolactone) highly aligned micro-fibers which formed collagen fibril-like bundles. Poly(ethylene glycol) diacrylate with decellularized bone was encased in the …